Journal ArticleDOI
Regional wall mechanics in the ischemic left ventricle: numerical modeling and dog experiments
Peter H. M. Bovendeerd,Theo Arts,Tammo Delhaas,Jacques M. Huyghe,D.H. van Campen,R. S. Reneman +5 more
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TLDR
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate.Abstract:
The mechanics of the ischemic left ventricle during a complete cardiac cycle were simulated using a finite-element model accounting for the thick-walled ventricular geometry, the fibrous nature of the myocardial tissue, and the dependency of active muscle fiber stress on time, strain, and strain rate. Ischemia was modeled by disabling the generation of active stress in a region comprising approximately 12% of total wall volume. In the model simulations, the approximately 12% reduction in the amount of normally contracting tissue resulted in an approximately 25% reduction in stroke work compared with the normal situation. The more-than-proportional loss of stroke work may partly be attributed to storage of elastic energy in the bulging ischemic region. Furthermore the mechanical performance in the nonischemic border zone deteriorated because of reduced systolic fiber stress (if fibers were in series with those in the ischemic region) or reduced fiber shortening (if fibers were parallel). The deformation pattern of the ventricle was asymmetric with respect to the ischemic region because of the anisotropy of the myocardial tissue. Epicardial fiber shortening in and around the ischemic region, as predicted from the model simulations, was in qualitative agreement with shortening, as measured in four dogs in which ischemia was induced by occlusion of the distal part of the left anterior interventricular coronary artery.read more
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Analytical model for predicting mechanotransduction effects in engineered cardiac tissue.
TL;DR: A mathematical model is developed to calculate the distribution of stress and strain in fibrous cardiac tissue and predicts patterns of mechanochemical coupling that results in localized fibrosis, altered gene expression, or the mechanoelectrical signaling events that potentiate cardiac arrhythmias.
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A comparison of numerical methods used for finite element modelling of soft tissue deformation
TL;DR: In this paper, soft tissue deformation is modelled using incompressible non-linear elasticity, with solutions computed using the finite element method, and a range of options available when using the...
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Adaptation of a Rabbit Myocardium Material Model for Use in a Canine Left Ventricle Simulation Study
TL;DR: The developed and testing of a material model of the canine LV myocardium, which will be used in ongoing simulations of the mechanics of the LV with fluid-structure interaction, and suitable for use in simulations of both idealized and realistic canine hearts.
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Kinematic analysis of left ventricular deformation in myocardial infarction using magnetic resonance cardiac tagging.
Frank W.L. Aelen,Theo Arts,Dave G.M. Sanders,Guillaume R.P. Thelissen,Frits W. Prinzen,Robert S. Reneman +5 more
TL;DR: The proposed method of kinematic analysis can be used to assess cardiac deformation in humans by analyzing images of more cross-sections simultaneously, so that the 3D location and the degree of infarction can be assessed efficiently.
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Assessment of regional left ventricular wall stress after myocardial infarction by echocardiography-based structural analysis.
Scott D. Solomon,Yumiko Aikawa,Mohamad S. Martini,Luis B. Rosario,Gotam Makker,David S. Gerson,Sally Greaves,Richard T. Lee +7 more
TL;DR: Anterior MI is associated with an increase in apical end-systolic wall stress compared with normal and infero-posterior MI, which may be an important stimulus for LV remodeling after anterior MI.