Regulation of erythropoiesis by hypoxia-inducible factors.
Citations
800 citations
458 citations
390 citations
310 citations
293 citations
Cites background from "Regulation of erythropoiesis by hyp..."
...In addition to the formation of blood vessels, an organism must stimulate the production of erythrocytes under hypoxia to increase O2 delivery; thus, a major role of HIF is to enhance transcription of genes controlling erythrocyte production [67]....
[...]
References
5,729 citations
"Regulation of erythropoiesis by hyp..." refers methods in this paper
...HIF-1 was first isolated from human Hep3B hepatoma cells using DNA sequences that were derived from the 3′-hypoxia enhancer of the EPO gene.(60,61) Together with HIF-2α (also known as endothelial PAS domain protein 1 (EPAS1) or HIF like factor, (HLF)), HIF-1α facilitates O2 delivery and cellular adaptation to hypoxia by stimulating a wide spectrum of biological processes that include angiogenesis, anaerobic glucose metabolism, mitochondrial biogenesis and others....
[...]
5,186 citations
4,845 citations
4,480 citations
3,188 citations