Regulation of germ cell development by intercellular signaling in the mammalian ovarian follicle.
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Cites background from "Regulation of germ cell development..."
...2004), gap junction proteins between granulosa cells (El-Hyek & Clarke 2015, Clarke 2018) and epidermal growth factor receptor expression in granulosa cells to prime the follicles for ovulation prior to LH action (El-Hayek et al....
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70 citations
Cites background from "Regulation of germ cell development..."
...On one hand, the granulosa cells send signals that trigger oocytes in primordial follicles to initiate growth, provide essential metabolites to growing oocytes, and regulate entry of fully grown oocytes into meiotic maturation [10, 16, 26, 27]....
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...TZPs Are Specialized Filopodia Prior to ovulation and fertilization, mammalian oocytes undergo a prolonged period of growth within the ovarian follicle [16]....
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References
1,541 citations
"Regulation of germ cell development..." refers background in this paper
...In prepuberal mice, a large fraction of the growing oocytes fail to achieve meiotic competence and oocytes of both prepuberal and adult mice show specific ultrastructural abnormalities, including an apparently disorganized cytoskeleton.(56,109) These abnormalities cannot be attributed to an autocrine effect of GDF9 on the oocyte, because deletion of Smad4 within the oocyte has no phenotypic effect....
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...Female mice lacking Gdf9 are anovulatory and sterile.(109) The granulosa cells fail to proliferate normally and do not generate more than a single layer around the growing oocyte....
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...The follicles of Gdf9 females also fail to acquire a thecal layer.(21,109,112) These cells arise from Focus Article wires....
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1,239 citations
"Regulation of germ cell development..." refers background in this paper
...Upon entry into the growth phase, the squamous granulosa cells that characterize the primordial follicle become cuboidal in shape and begin to proliferate mitotically so that they continue to fully cover the expanding surface of the growing oocyte.(19,20) These follicles, now termed primary, are delimited by a basement membrane that lies apposed to the basal side of the granulosa cells....
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"Regulation of germ cell development..." refers background in this paper
...Factors secreted by the oocyte do, however, regulate the differentiation of the granulosa cells and even the thecal calls.(21,87,101) GDF9 and bone morphogenetic protein (BMP) 15 are closely related members of the transforming growth factor (TGF) β superfamily....
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812 citations
"Regulation of germ cell development..." refers background in this paper
...Finally, the transcription factor, FOXO3, translocates from the nucleus to the cytoplasm at an early stage of growth and genetic deletion of Foxo3 cause most oocytes in primordial follicles to begin to grow.(59,71) Similarly, deletion of the oocyte-specific transcription factor Sohlh2 or oocyte-specific deletion of transcription factor Lhx8 also trigger initiation of oocyte growth, apparently independently of signals from the granulosa cells....
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