Journal ArticleDOI
Regulation of naive T cell differentiation by varying the potency of TCR signal transduction.
David Leitenberg,Kim Bottomly +1 more
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This work proposes a model in which specific signals are required to initiate Th2 differentiation, but that this pathway can be inhibited following a strong TCR stimulus.About:
This article is published in Seminars in Immunology.The article was published on 1999-08-01. It has received 107 citations till now. The article focuses on the topics: Naive T cell & T-cell receptor.read more
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Calcium signalling in lymphocyte activation and disease.
TL;DR: This Review focuses on the role of Ca2+ signals in lymphocyte functions, the signalling pathways leading toCa2+ influx, the function of the recently discovered regulators of Ca1+ influx (STIM and ORAI), and the relationship between Ca2- signals and diseases of the immune system.
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RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems
Koichi Kobayashi,Naohiro Inohara,Lorraine D. Hernandez,Jorge E. Galán,Gabriel Núñez,Charles A. Janeway,Ruslan Medzhitov,Richard A. Flavell +7 more
TL;DR: Rip2 is therefore a signal transducer and integrator of signals for both the innate and adaptive immune systems.
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CARMA1, BCL-10 and MALT1 in lymphocyte development and activation.
TL;DR: Recent advances in the understanding of the molecular and biological functions ofCARMA1, BCL-10 and MALT1 are discussed, which reveal additional, previously unexpected roles for these proteins in the development of B and T cells, and in the CD40- and lipopolysaccharide-dependent activation of B cells.
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Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis.
Jesse E. Jun,Lauren Elizabeth Wilson,Carola G. Vinuesa,Sylvie Lesage,Mathieu Blery,Lisa A. Miosge,Matthew C. Cook,Edyta M. Kucharska,Hiromitsu Hara,Hiromitsu Hara,Josef M. Penninger,Josef M. Penninger,Heather Domashenz,Nancy A. Hong,Richard Glynne,Keats Nelms,Christopher C. Goodnow +16 more
TL;DR: These results define Carma-1 as a key regulator of the plasticity in antigen receptor signaling that underpins opposing mechanisms of immunity and tolerance.
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In the absence of IL-12, CD4(+) T cell responses to intracellular pathogens fail to default to a Th2 pattern and are host protective in an IL-10(-/-) setting.
TL;DR: MyD88-deficient animals exposed to a Th1 microbial stimulus developed a pure Th2 response, arguing that this signaling element plays a more critical function than IL-12 in determining pathogen-induced CD4 polarization.
References
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TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
TL;DR: Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed.
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The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells
TL;DR: In transgenic mice, elevated GATA-3 in CD4 T cells caused Th2 cytokine gene expression in developing Th1 cells, indicating that Gata-3 is necessary and sufficient for Th2inflammatory gene expression.
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Three-dimensional segregation of supramolecular activation clusters in T cells
TL;DR: The three-dimensional distribution of receptors and intracellular proteins that cluster at the contacts between T cells and APCs during antigen-specific interactions, Surprisingly, instead of showing uniform oligomerization, these proteins clustered into segregated three- dimensional domains within the cell contacts.
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Differential activation of transcription factors induced by Ca2+ response amplitude and duration
TL;DR: It is reported here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro–inflammatory transcriptional regulators NF-κB, c-Jun N-terminal kinase (JNK) and NFAT, revealing a mechanism by which a multifunctional second messenger such as Ca2+ can achieve specificity in signalling to the nucleus.
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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells
TL;DR: It is demonstrated that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses toIL-4 lymphocytes.