Journal ArticleDOI
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Reads0
Chats0
TLDR
In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of post Synaptic action potentials and unitary excitatory postsynaptic potentials was found to induce changes in EPSPs.Abstract:
Activity-driven modifications in synaptic connections between neurons in the neocortex may occur during development and learning In dual whole-cell voltage recordings from pyramidal neurons, the coincidence of postsynaptic action potentials (APs) and unitary excitatory postsynaptic potentials (EPSPs) was found to induce changes in EPSPs Their average amplitudes were differentially up- or down-regulated, depending on the precise timing of postsynaptic APs relative to EPSPs These observations suggest that APs propagating back into dendrites serve to modify single active synaptic connections, depending on the pattern of electrical activity in the pre- and postsynaptic neuronsread more
Citations
More filters
Book
Reinforcement Learning: An Introduction
TL;DR: This book provides a clear and simple account of the key ideas and algorithms of reinforcement learning, which ranges from the history of the field's intellectual foundations to the most recent developments and applications.
Journal ArticleDOI
Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
Guo-Qiang Bi,Mu-ming Poo +1 more
TL;DR: The results underscore the importance of precise spike timing, synaptic strength, and postsynaptic cell type in the activity-induced modification of central synapses and suggest that Hebb’s rule may need to incorporate a quantitative consideration of spike timing that reflects the narrow and asymmetric window for the induction of synaptic modification.
Book
Theoretical Neuroscience: Computational and Mathematical Modeling of Neural Systems
Peter Dayan,L. F. Abbott +1 more
TL;DR: This text introduces the basic mathematical and computational methods of theoretical neuroscience and presents applications in a variety of areas including vision, sensory-motor integration, development, learning, and memory.
Book
Spiking Neuron Models: Single Neurons, Populations, Plasticity
TL;DR: A comparison of single and two-dimensional neuron models for spiking neuron models and models of Synaptic Plasticity shows that the former are superior to the latter, while the latter are better suited to population models.
Journal ArticleDOI
Synaptic plasticity and memory: an evaluation of the hypothesis
TL;DR: It is concluded that a wealth of data support the notion that synaptic plasticity is necessary for learning and memory, but that little data currently supports the notion of sufficiency.
References
More filters
Journal ArticleDOI
A synaptic model of memory: long-term potentiation in the hippocampus
TL;DR: The best understood form of long-term potentiation is induced by the activation of the N-methyl-d-aspartate receptor complex, which allows electrical events at the postsynaptic membrane to be transduced into chemical signals which, in turn, are thought to activate both pre- and post Synaptic mechanisms to generate a persistent increase in synaptic strength.
Journal ArticleDOI
The organization of behavior.
TL;DR: Reading is a need and a hobby at once and this condition is the on that will make you feel that you must read.
Journal ArticleDOI
Synchronization of cortical activity and its putative role in information processing and learning
TL;DR: The first measurements of the electrical activity of the brain revealed prominent oscillatory activity, and until more recently the analysis of oscillatory patterns in the electroencephalogram and in field potentials recorded with intracerebral macroelectrodes has remained a major research tool of neuro physiology.
Journal ArticleDOI
Active propagation of somatic action potentials into neocortical pyramidal cell dendrites
Greg J. Stuart,Bert Sakmann +1 more
TL;DR: To determine the site of initiation of action potentials, simultaneous whole-cell recordings were made from the soma and the apical dendrite or axon of the same cell and showed thataction potentials are initiated first in the axon and then actively propagate back into the dendritic tree.
Related Papers (5)
Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic Strength, and Postsynaptic Cell Type
Guo-Qiang Bi,Mu-ming Poo +1 more