Regulatory T cells in nonlymphoid tissues
Reads0
Chats0
TLDR
This Review summarizes recent findings in this new field, discussing knowns and unknowns about the origin, phenotype, function and memory of nonlymphoid tissue-resident Treg cells.Abstract:
Both Foxp3(+)CD4(+) regulatory T cells (Treg cells) and local immune responses in nonlymphoid tissues have long been recognized as important elements of a well-orchestrated immune system, but only recently have these two fields of study begun to intersect. There is growing evidence that Treg cells are present in various nonlymphoid tissues in health and disease, that they have a unique phenotype and that their functions go beyond the classical modulation of immune responses. Thus, tissue Treg cells might add yet another level to classification of the Treg cell compartment into functional and/or phenotypic subtypes. In this Review, we summarize recent findings in this new field, discussing knowns and unknowns about the origin, phenotype, function and memory of nonlymphoid tissue-resident Treg cells.read more
Citations
More filters
Journal ArticleDOI
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system
Thaher Pelaseyed,Joakim H. Bergström,Jenny K. Gustafsson,Anna Ermund,George M. H. Birchenough,André Schütte,Sjoerd van der Post,Frida Svensson,Ana M. Rodríguez-Piñeiro,Elisabeth E. L. Nyström,Catharina Wising,Malin E. V. Johansson,Gunnar C. Hansson +12 more
TL;DR: The mucus and epithelial cells of the gastrointestinal tract are the primary gate keepers and controllers of bacterial interactions with the host immune system, but the understanding of this relationship is still in its infancy.
Journal ArticleDOI
The alarmin IL-33 promotes regulatory T-cell function in the intestine
Chris Schiering,Thomas Krausgruber,Agnieszka Chomka,Anja Fröhlich,Krista Adelmann,Elizabeth A. Wohlfert,Johanna Pott,Thibault Griseri,Julia Bollrath,Ahmed N. Hegazy,Oliver J. Harrison,Benjamin M. J. Owens,Max Löhning,Yasmine Belkaid,Padraic G. Fallon,Fiona Powrie +15 more
TL;DR: It is shown in mice that the IL-33 receptor ST2 is preferentially expressed on colonic Treg cells, where it promotes Treg function and adaptation to the inflammatory environment, and suggests that the balance between IL- 33 and IL-23 may be a key controller of intestinal immune responses.
Journal ArticleDOI
Tissue-resident memory T cells: local specialists in immune defence
TL;DR: This Review discusses the major advances and the emerging concepts in this field, summarizes what is known about the differentiation and the protective functions of tissue-resident memory T cells in different tissues in the body and highlights key unanswered questions.
Journal ArticleDOI
A Distinct Function of Regulatory T Cells in Tissue Protection
Nicholas Arpaia,Jesse A. Green,Bruno Moltedo,Aaron Arvey,Saskia Hemmers,Shaopeng Yuan,Piper M. Treuting,Alexander Y. Rudensky +7 more
TL;DR: The results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance-distinct from their role in suppression of immune responses and inflammation-and that these two essential Treg cell functions are invoked by separable cues.
Journal ArticleDOI
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells
Esen Sefik,Naama Geva-Zatorsky,Sungwhan F. Oh,Liza Konnikova,David Zemmour,Abigail Manson McGuire,Dalia Burzyn,Adriana Ortiz-Lopez,Mercedes Lobera,Jianfei Yang,Shomir Ghosh,Ashlee M. Earl,Scott B. Snapper,Ray Jupp,Dennis L. Kasper,Diane Mathis,Diane Mathis,Christophe Benoist,Christophe Benoist +18 more
TL;DR: It is reported that symbiotic members of the human gut microbiota induce a distinct Treg population in the mouse colon, which constrains immuno-inflammatory responses.
References
More filters
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
TL;DR: A role for TNF-alpha in obesity and particularly in the insulin resistance and diabetes that often accompany obesity is indicated.
Journal ArticleDOI
Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.
Tyler J. Curiel,George Coukos,Linhua Zou,Xavier Alvarez,Pui Cheng,Peter Mottram,Melina Evdemon-Hogan,Jose R. Conejo-Garcia,Lin Zhang,Matthew E. Burow,Yun Zhu,Shuang Wei,Ilona Kryczek,Ben Daniel,Alan N. Gordon,Leann Myers,Andrew A. Lackner,Mary L. Disis,Keith L. Knutson,Lieping Chen,Weiping Zou +20 more
TL;DR: It is shown, in detailed studies of CD4+CD25+FOXP3+ Treg cells in 104 individuals affected with ovarian carcinoma, that human tumor T Reg cells suppress tumor-specific T cell immunity and contribute to growth of human tumors in vivo.
Journal ArticleDOI
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Koji Atarashi,Takeshi Tanoue,Tatsuichiro Shima,Akemi Imaoka,Tomomi Kuwahara,Yoshika Momose,Genhong Cheng,Sho Yamasaki,Takashi Saito,Yusuke Ohba,Tadatsugu Taniguchi,Kiyoshi Takeda,Shohei Hori,Ivaylo I. Ivanov,Yoshinori Umesaki,Kikuji Itoh,Kenya Honda,Kenya Honda +17 more
TL;DR: Oral inoculation of Clostridium during the early life of conventionally reared mice resulted in resistance to colitis and systemic immunoglobulin E responses in adult mice, suggesting a new therapeutic approach to autoimmunity and allergy.