Reinforcement signalling in Drosophila; dopamine does it all after all.
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TLDR
It now seems crucial to understand how the dopaminergic neurons are controlled and what the released dopamine does to the underlying circuits to convey opposite valence.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2013-06-01 and is currently open access. It has received 233 citations till now. The article focuses on the topics: Dopaminergic & Reward system.read more
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The neuronal architecture of the mushroom body provides a logic for associative learning
Yoshinori Aso,Daisuke Hattori,Yang Yu,Rebecca M. Johnston,Nirmala Iyer,Teri T.B. Ngo,Heather Dionne,Larry F. Abbott,Richard Axel,Hiromu Tanimoto,Gerald M. Rubin +10 more
TL;DR: The elucidation of the complement of neurons of the MB provides a comprehensive anatomical substrate from which one can infer a functional logic of associative olfactory learning and memory.
Journal ArticleDOI
The complete connectome of a learning and memory centre in an insect brain
Katharina Eichler,Feng Li,Ashok Litwin-Kumar,Youngser Park,Ingrid Andrade,Casey M Schneider-Mizell,Timo Saumweber,Annina Huser,Claire Eschbach,Bertram Gerber,Bertram Gerber,Richard D. Fetter,James W Truman,Carey E. Priebe,Larry F. Abbott,Andreas S. Thum,Marta Zlatic,Marta Zlatic,Albert Cardona,Albert Cardona +19 more
TL;DR: It is found that most Kenyon cells integrate random combinations of inputs but that a subset receives stereotyped inputs from single projection neurons, which maximizes performance of a model output neuron on a stimulus discrimination task.
Journal ArticleDOI
Coordinated and Compartmentalized Neuromodulation Shapes Sensory Processing in Drosophila
TL;DR: It is shown that the Drosophila mushroom body functions like a switchboard in which neuromodulation reroutes the same odor signal to different behavioral circuits, depending on the state and experience of the fly.
Journal ArticleDOI
A connectome of a learning and memory center in the adult Drosophila brain
Shin-ya Takemura,Yoshinori Aso,Toshihide Hige,Allan M. Wong,Zhiyuan Lu,C. Shan Xu,Patricia K. Rivlin,Harald F. Hess,Ting Zhao,Toufiq Parag,Stuart Berg,Gary B. Huang,William T. Katz,Donald J. Olbris,Stephen M. Plaza,Lowell Umayam,Roxanne Aniceto,Lei-Ann Chang,Shirley Lauchie,Omotara Ogundeyi,Christopher Ordish,Aya Shinomiya,Christopher Sigmund,Satoko Takemura,Julie Tran,Glenn C. Turner,Gerald M. Rubin,Louis K. Scheffer +27 more
TL;DR: This work reconstructed the morphologies and synaptic connections of all 983 neurons within the three functional units, or compartments, that compose the adult MB’s α lobe, using a dataset of isotropic 8 nm voxels collected by focused ion-beam milling scanning electron microscopy.
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Defining and assessing animal pain
TL;DR: Criteria that demonstrate, beyond a reasonable doubt, whether animals of a given species experience pain are defined that are vital to inform whether to alleviate pain or to drive the refinement of procedures to reduce invasiveness.
References
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Journal ArticleDOI
A Neural Substrate of Prediction and Reward
TL;DR: Findings in this work indicate that dopaminergic neurons in the primate whose fluctuating output apparently signals changes or errors in the predictions of future salient and rewarding events can be understood through quantitative theories of adaptive optimizing control.
Journal ArticleDOI
Dopamine in Motivational Control: Rewarding, Aversive, and Alerting
TL;DR: It is proposed that dopamine neurons come in multiple types that are connected with distinct brain networks and have distinct roles in motivational control, and it is hypothesized that these dopaminergic pathways for value, salience, and alerting cooperate to support adaptive behavior.
Journal ArticleDOI
Two types of dopamine neuron distinctly convey positive and negative motivational signals
TL;DR: It is shown that some dopamine neurons were excited by reward-predicting stimuli and inhibited by airpuff-p Predicting stimuli, as the value hypothesis predicts, but this is true only for a subset of dopamine neurons.
Journal ArticleDOI
Mushroom body memoir: From maps to models
TL;DR: Genetic intervention in the fly Drosophila melanogaster has provided strong evidence that the mushroom bodies of the insect brain act as the seat of a memory trace for odours, and the development of a circuit model that addresses this function might allow the mushrooms to throw light on the basic operating principles of the brain.
Journal ArticleDOI
Neuron-type-specific signals for reward and punishment in the ventral tegmental area
TL;DR: VTA GABAergic neurons signal expected reward, a key variable for dopaminergic neurons to calculate reward prediction error, and are ‘tagged’ and identified based on their responses to optical stimulation while recording.
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Mushroom body output neurons encode valence and guide memory-based action selection in Drosophila
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