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Journal ArticleDOI

Relationship between Fatty-Acid Composition of Platelets and Platelet Aggregation in Rat and Man RELATION TO THROMBOSIS

Serge Renaud1, K. Kuba1, C. Goulet1, Y. Lemire1, Claude Allard1 
01 May 1970-Circulation Research (Lippincott Williams & Wilkins)-Vol. 26, Iss: 5, pp 553-564
TL;DR: In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition.
Abstract: Male rats fed a diet rich in butter or stearic acid presented a marked predisposition to endotoxin-initiated thrombosis. This was preceded by hypercholesterolemia, hypercoagulability, and an increased susceptibility of platelets to thrombin-induced aggregation. In contrast to this, feeding of corn oil or linoleic or oleic acids did not result in such marked changes in the blood or in severe thrombosis. Gas-liquid chromatographic analysis of total lipids of platelet and plasma indicated that the thrombogenic fat or fatty acid resulted in a highly significant increase, mostly in the platelets, of the ratio of saturated + monounsaturated to polyunsaturated fatty acids (S+M)/P. In patients who had suffered a myocardial infarction as compared with men without risk factors for coronary heart disease, an increase in the (S+M)/P in plasma and platelets was also observed. Among 17 active middle-aged businessmen, the five who presented signs of coronary heart disease also showed the highest susceptibility to thrombin-induced aggregation, but not to ADP or collagen. In these 17 subjects, the results of the thrombin aggregation could be correlated with the platelet (S+M)/P, but not with the plasma or platelet cholesterol. In both the rat and man, a high thrombotic tendency may be associated with a platelet hypersusceptibility to thrombin which, in turn, is related to changes in fatty-acid composition.
Citations
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Journal ArticleDOI
TL;DR: The cholesterol content of LJpoproteins and the rates of Synthesis and Catabolism have changed, as well as the composition of the Fatty Acid Composition and Upoprotein Metabolism.
Abstract: Polyunsaturated Fatty Acid Families and Interrelationships Omega-6 Fatty Acids and Plasma Lipids Plasma Cholesterol Plasma Triglycerlde Plasma LJpoprotelns and Apolipoproteins Hypolipldemic Mechanisms of Linoleic Acid Decrease in Cholesterol Absorption Increase in Fecal Steroid Excretion Reduced Cholesterol Synthesis and the Transfer of Cholesterol to the Tissues Decrease in Cholesterol Content of LJpoproteins Changes in the Rates of Synthesis and Catabolism of LJpoproteins Membrane Fatty Acid Composition and Upoprotein Metabolism

666 citations

Journal ArticleDOI
TL;DR: It is concluded that the fatty acid compositions of the glycerolphospholipids of plasma, RBCs, and platelets reflect the major dietary fatty acids.

304 citations

Journal ArticleDOI
TL;DR: There was a progressive inverse relation between adipose linoleic acid and the estimated relative risk of AP, but it was confounded by smoking habit, and eicosapentaenoic acid in platelet membranes was lower in AMI patients than in controls, this difference was not significant.

228 citations

Journal ArticleDOI
TL;DR: The platelet rebound effect of alcohol drinking was not observed with moderate red wine consumption in man and could be associated with an excess of lipid peroxides known to increase platelet reactivity, especially to thrombin.

190 citations

References
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Journal ArticleDOI

1,782 citations


"Relationship between Fatty-Acid Com..." refers methods in this paper

  • ...), according to the technique of Metcalfe and Schmitz (12)....

    [...]

  • ...The fatty acids were methylated by heating for 2 minutes in a boiling-water bath, with 3 ml of boron trifluoride methanol (Applied Science Laboratories Inc., State College, Pa.), according to the technique of Metcalfe and Schmitz (12)....

    [...]

Journal ArticleDOI
24 Aug 1957-JAMA
TL;DR: Each new research adds detail, reduces areas of uncertainty, and provides further reason to believe that along the line of this hypothesis the authors may hope to find effective measures to reduce the incidence of coronary heart disease.
Abstract: Researches ranging from laboratory experiments to epidemiology on a world-wide basis have led to the hypothesis that the fat content of the habitual diets of populations has an important effect on the frequency of coronary heart disease in those populations. The general nature and some of the evidence for this hypothesis have been summarized several times in recent years, 1 but progress in this field manages to outdate each new resume by the time it reaches print. Not that the previously cited facts or the hypothesis itself have been found to be erroneous; on the contrary, each new research adds detail, reduces areas of uncertainty, and, so far, provides further reason to believe that along the line of this hypothesis we may hope to find effective measures to reduce the incidence of coronary heart disease. As it now stands, the hypothesis may be stated simply as follows: Though many factors

200 citations


"Relationship between Fatty-Acid Com..." refers background in this paper

  • ...related to the ingestion of animal fats (6, 7),...

    [...]

Journal Article

179 citations


"Relationship between Fatty-Acid Com..." refers methods in this paper

  • ...(20), the platelet-aggregation technique used in the present studies was highly reproducible in the human subjects, and the results could be compared from day to day....

    [...]

Journal ArticleDOI
TL;DR: In cases of hypercholesterolaemia, hyperphospholipidaemia and hyperglyceridaemia there appear in the serum additional esters which contain more saturated and mono-unsaturated and fewer polyunsaturated fatty acids.

170 citations


"Relationship between Fatty-Acid Com..." refers result in this paper

  • ...In atherosclerotic patients, some workers have reported similar results on different serum lipids fractions (14, 15) and even in the aorta (16), while others (17) have failed to demonstrate such changes....

    [...]

Journal ArticleDOI
Marian A. Packham1, E. S. Warrior1, M. F. Glynn1, A. S. Senyi1, J F Mustard1 
TL;DR: It was found that phenylbutazone prolonged platelet survival to more than twice the normal time and reduced platelet turnover by nearly 50%.
Abstract: Sulfinpyrazone and phenylbutazone block the aggregating action of collagen, antigen-antibody complexes, and gamma globulin-coated surfaces on blood platelets. These drugs do not block the action of ADP or thrombin. Inhibition of surface-induced aggregation appears to be the result of a decreased response of the platelets to surface stimuli, giving rise to diminished release of platelet constituents, such as ADP and serotonin. The intravenous infusion of these drugs produced results similar to those found in the in vitro experiments. Administration of phenylbutazone in doses sufficient to produce marked suppression of the platelet-collagen reaction impaired hemostatic plug formation at the ends of transected mesenteric vessels in rabbits. Since platelet function is considered a factor influencing platelet survival, the effect of phenylbutazone on platelet survival was examined. It was found that phenylbutazone prolonged platelet survival to more than twice the normal time and reduced platelet turnover by nearly 50%. These studies show that drugs which suppress platelet response to surface stimuli alter platelet function in vivo.

163 citations


Additional excerpts

  • ...5 g/liter), as described by others (11)....

    [...]