Relationship between Right Ventricular Longitudinal Strain, Invasive Hemodynamics, and Functional Assessment in Pulmonary Arterial Hypertension
Jae-Hyeong Park,Jae-Hyeong Park,Kenya Kusunose,Kenya Kusunose,Deborah H Kwon,Margaret M. Park,Margaret M. Park,Serpil C. Erzurum,Serpil C. Erzurum,James D. Thomas,Richard A. Grimm,Brian P. Griffin,Thomas H. Marwick,Thomas H. Marwick,Zoran B. Popović +14 more
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RVLS correlates with functional and invasive hemodynamic parameters in PAH patients and decrease of mPAP and PVR as a result of treatment was associated with improvement of RVLS.Abstract:
Background and Objectives: Right ventricular longitudinal strain (RVLS) is a new parameter of RV function. We evaluated the relationship of RVLS by speckle-tracking echocardiography with functional and invasive parameters in pulmonary arterial hypertension (PAH) patients. Subjects and Methods: Thirty four patients with World Health Organization group 1 PAH (29 females, mean age 45±13 years old). RVLS were analyzed with velocity vector imaging. Results: Patients with advanced symptoms {New York Heart Association (NYHA) functional class III/IV} had impaired RVLS in global RV (RVLSglobal, -17±5 vs. -12±3%, p<0.01) and RV free wall (RVLSFW, -19±5 vs. -14±4%, p<0.01 to NYHA class I/II). Baseline RVLSglobal and RVLSFW showed significant correlation with 6-minute walking distance (r=-0.54 and r=-0.57, p<0.01 respectively) and logarithmic transformation of brain natriuretic peptide concentration (r=0.65 and r=0.65, p<0.01, respectively). These revealed significant correlations with cardiac index (r=-0.50 and r=-0.47, p<0.01, respectively) and pulmonary vascular resistance (PVR, r=0.45 and r=0.45, p=0.01, respectively). During a median follow-up of 33 months, 25 patients (74%) had follow-up examinations. Mean pulmonary arterial pressure (mPAP, 54±13 to 46±16 mmHg, p=0.03) and PVR (11±5 to 6±2 wood units, p<0.01) were significantly decreased with pulmonary vasodilator treatment. RVLSglobal (-12±5 to -16±5%, p<0.01) and RVLSFW (-14±5 to -18±5%, p<0.01) were significantly improved. The decrease of mPAP was significantly correlated with improvement of RVLS global (r=0.45, p<0.01) and RVLSFW (r=0.43, p<0.01). The PVR change demonstrated significant correlation with improvement of RVLS global (r=0.40, p<0.01). Conclusion: RVLS correlates with functional and invasive hemodynamic parameters in PAH patients. Decrease of mPAP and PVR as a result of treatment was associated with improvement of RVLS. (Korean Circ J 2015;45(5):398-407)read more
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Rationale and design of a screening study to detect schistosomiasis‐associated pulmonary hypertension in Ethiopia and Zambia
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TL;DR: If successful, this study will demonstrate feasibility of conducting prospective cohort studies of SchPAH screening in schistosomiasis‐endemic regions of Africa, and provide initial data on clinic‐based disease prevalence and potential mechanistic biomarkers underlying disease pathogenesis.
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TL;DR: In this paper, the authors investigated whether pPTT elevated in patients with HIV infection compared to healthy controls and its association with echocardiographic indices of right ventricular functions, including tricuspid annular peak systolic excursion (TAPSE) and right ventricle fractional area change (FAC).
Journal ArticleDOI
Correlation Between Right Ventricular Echocardiography Measurements and Functional Capacity in Patients With Pulmonary Arterial Hypertension.
Joyce Woo,Michael P. DiLorenzo,Eliana H Rosenzweig,Nikhil Pasumarti,Gerson A. Vallencia Villeda,Erika Berman-Rosenzweig,Usha Krishnan +6 more
TL;DR: In this article , the relationship between functional capacity by accelerometry and right ventricular measurements on echocardiography for patients with pulmonary arterial hypertension (PAH) was evaluated.
Journal ArticleDOI
Correlation Between Right Ventricular Echocardiography Measurements and Functional Capacity in Patients With Pulmonary Arterial Hypertension
TL;DR: In this article , the relationship between functional capacity by accelerometry and right ventricular measurements on echocardiography for patients with pulmonary arterial hypertension (PAH) was evaluated.
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Evaluation of right ventricular function and pulmonary hypertension
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TL;DR: The fundamental concepts of RV strain analysis, its measurement, normal values, and emerging clinical applications are described, and there is evidence that RV free-wall longitudinal systolic strain using speckle-tracking echocardiography is reproducible, feasible, and a highly prognostic metric of RV function.
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TL;DR: Mortality was most closely associated with right ventricular hemodynamic function and can be characterized by means of an equation using three variables: mean pulmonary artery pressure, mean right atrial pressure, and cardiac index.
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