Journal ArticleDOI
Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults.
Antoine Hone-Blanchet,Anastasia Bohsali,Lisa C. Krishnamurthy,Lisa C. Krishnamurthy,Salman Syed Shahid,Salman Syed Shahid,Qixiang Lin,Liping Zhao,David W. Loring,Felicia C. Goldstein,Samantha E. John,Candace C. Fleischer,Candace C. Fleischer,Allan I. Levey,James J. Lah,Deqiang Qiu,Deqiang Qiu,Bruce Crosson,Bruce Crosson +18 more
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TLDR
In this article, the effect of aging and cerebrospinal fluid levels of Aβ1-42 and tau on frontal metabolites measured with proton magnetic resonance spectroscopy (MRS) and cognition in cognitively normal older adults (n = 144; age range 50-85) was investigated.About:
This article is published in Neurobiology of Aging.The article was published on 2022-01-01. It has received 6 citations till now. The article focuses on the topics: Creatine & Internal medicine.read more
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Journal ArticleDOI
Acute administration of ketone beta-hydroxybutyrate downregulates 7T proton magnetic resonance spectroscopy-derived levels of anterior and posterior cingulate GABA and glutamate in healthy adults
Antoine Hone-Blanchet,Botond Antal,Liam McMahon,Andrew Lithen,Nathan A. Smith,Steven M. Stufflebeam,Yi-Fen Yen,Alexander P. Lin,Bruce G. Jenkins,Lilianne R. Mujica-Parodi,Eva-Maria Ratai +10 more
TL;DR: Results show that administration of ketones acutely impacts main inhibitory and excitatory transmitters in the whole fasting cortex, compared to normal energy substrate glucose, suggesting an increased sensitivity to ketones with brain aging.
Journal ArticleDOI
Frontal Metabolites and Alzheimer's Disease Biomarkers in Healthy Older Women and Women Diagnosed with Mild Cognitive Impairment.
Antoine Hone-Blanchet,Anastasia Bhosali,Lisa C. Krishnamurthy,Salman Shahid,Qixiang Lin,Liping Zhao,Aditya Singh Bisht,Samantha E. John,David W. Loring,Felicia C. Goldstein,Allan I. Levey,James J. Lah,Deqiang Qiu,Bruce Crosson +13 more
TL;DR: This study is the first to demonstrate a strong association between frontal GABA+ levels and neurological aging in a sample consisting exclusively of healthy older women with various levels of CSF tau and Aβ 1-42 and women with MCI.
Journal ArticleDOI
Based on 1H NMR and LC-MS metabolomics reveals biomarkers with neuroprotective effects in multi-parts ginseng powder
Nanxi Zhang,Yinping Yang,Chunnan Li,Kaiyue Zhang,Xiao-chen Gao,Jiaming Shen,Yue-Hua Wang,Duanduan Cheng,Jingwei Lv,Jiaming Sun +9 more
TL;DR: Wang et al. as mentioned in this paper used 1H NMR and LC-MS metabolomics techniques and multivariate statistical analysis techniques to analyze the differential metabolites (DMs) in ginseng main root (TR), lateral root (LR) and rhizome (RZ).
Journal ArticleDOI
MRS in neurodegenerative dementias, prodromal syndromes and at‐risk states: A systematic review of the literature
TL;DR: In this paper , a review aims to determine how increased MRI field strengths, new acquisition protocols and new processing techniques have altered our understanding of MRS neurometabolic markers in neurodegenerative dementias.
Journal ArticleDOI
APOE Peripheral and Brain Impact: APOE4 Carriers Accelerate Their Alzheimer Continuum and Have a High Risk of Suicide in PM2.5 Polluted Cities
Lilian Calderón-Garcidueñas,Jacqueline Hernández-Luna,Mario Aiello-Mora,Rafael Brito-Aguilar,Pablo Evelson,Rodolfo Villarreal-Rios,Ricardo Torres-Jardón,Alberto Ayala,Partha Sarathi Mukherjee +8 more
TL;DR: In this article , the authors discuss major mechanistic players associated with the APOE alleles' effects in humans to understand their impact from conception through all life stages and the importance of detrimental, synergistic environmental exposures.
References
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Controlling the false discovery rate: a practical and powerful approach to multiple testing
Yoav Benjamini,Yosef Hochberg +1 more
TL;DR: In this paper, a different approach to problems of multiple significance testing is presented, which calls for controlling the expected proportion of falsely rejected hypotheses -the false discovery rate, which is equivalent to the FWER when all hypotheses are true but is smaller otherwise.
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The Montreal Cognitive Assessment, MoCA: A Brief Screening Tool For Mild Cognitive Impairment
Ziad S. Nasreddine,Natalie A. Phillips,Valérie Bédirian,Simon Charbonneau,Victor Whitehead,Isabelle Collin,Jeffrey L. Cummings,Howard Chertkow +7 more
TL;DR: A 10‐minute cognitive screening tool (Montreal Cognitive Assessment, MoCA) to assist first‐line physicians in detection of mild cognitive impairment (MCI), a clinical state that often progresses to dementia.
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NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease
Clifford R. Jack,David A. Bennett,Kaj Blennow,Maria C. Carrillo,Billy Dunn,Samantha Budd Haeberlein,David M. Holtzman,William J. Jagust,Frank Jessen,Jason Karlawish,Enchi Liu,José Luis Molinuevo,Thomas J. Montine,Creighton H. Phelps,Katherine P. Rankin,Christopher C. Rowe,Philip Scheltens,Eric Siemers,Heather M. Snyder,Reisa A. Sperling,Cerise L Elliott,Eliezer Masliah,Laurie M. Ryan,Nina Silverberg +23 more
TL;DR: This research framework seeks to create a common language with which investigators can generate and test hypotheses about the interactions among different pathologic processes (denoted by biomarkers) and cognitive symptoms and envision that defining AD as a biological construct will enable a more accurate characterization and understanding of the sequence of events that lead to cognitive impairment that is associated with AD.
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Neuroinflammation in Alzheimer's disease
Michael T. Heneka,Monica J. Carson,Joseph El Khoury,Gary E. Landreth,Frederic Brosseron,Douglas L. Feinstein,Andreas H. Jacobs,Tony Wyss-Coray,Tony Wyss-Coray,Javier Vitorica,Richard M. Ransohoff,Karl Herrup,Sally A. Frautschy,Bente Finsen,Guy C. Brown,Alexei Verkhratsky,Alexei Verkhratsky,Alexei Verkhratsky,Koji Yamanaka,Jari Koistinaho,Eicke Latz,Eicke Latz,Annett Halle,Gabor C. Petzold,Terrence Town,Dave Morgan,Mari L. Shinohara,V. Hugh Perry,Clive Holmes,Clive Holmes,Nicolas G. Bazan,David J. Brooks,Stéphane Hunot,Bertrand Joseph,Nikolaus Deigendesch,Olga Garaschuk,Erik Boddeke,Charles A. Dinarello,John C.S. Breitner,Greg M. Cole,Douglas T. Golenbock,Markus P. Kummer +41 more
TL;DR: Genome-wide analysis suggests that several genes that increase the risk for sporadic Alzheimer's disease encode factors that regulate glial clearance of misfolded proteins and the inflammatory reaction.
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Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
Lars M. Ittner,Jürgen Götz +1 more
TL;DR: Novel findings that have shifted understanding of the role of tau in the pathogenesis of Alzheimer's disease towards being a crucial partner of amyloid-β are reviewed.
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