Renal clearable inorganic nanoparticles: A new frontier of bionanotechnology
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TLDR
This review summarizes size, shape, surface chemistry and biodegradation considerations in the design of renal clearable inorganic NPs and their strengths over conventional non-renal clearableNPs and small-molecule contrast agents in tumor targeting and their biomedical implications beyond tumor targeting.About:
This article is published in Materials Today.The article was published on 2013-12-01 and is currently open access. It has received 277 citations till now.read more
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Cancer nanomedicine: a review of recent success in drug delivery
TL;DR: The clinical trials of Onivyde leading to its approval in 2015 by the Food and Drug Adminstration are highlighted as a case study in the recent clinical success of nanomedicine against cancer.
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Degradability and Clearance of Silicon, Organosilica, Silsesquioxane, Silica Mixed Oxide, and Mesoporous Silica Nanoparticles.
TL;DR: The degradability and clearance timelines of various siliceous nanomaterials are compared and it is highlighted that researchers can select a specific nanommaterial in this large family according to the targeted applications and the required clearance kinetics.
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Tailored functionalization of iron oxide nanoparticles for MRI, drug delivery, magnetic separation and immobilization of biosubstances.
TL;DR: Tuning the surface chemistry and design of magnetic nanoparticles are described in relation to their applicability in advanced medical technologies and biotechnologies including magnetic resonance imaging (MRI) contrast agents, targeted drug delivery, magnetic separations and immobilizations of proteins, enzymes, antibodies, targeting agents and other biosubstances.
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CuS Nanodots with Ultrahigh Efficient Renal Clearance for Positron Emission Tomography Imaging and Image-Guided Photothermal Therapy
TL;DR: As a first example of PET-visible, renal-clearable inorganic nanomaterials with peak absorption in the near-infrared region, CuS NDs represent a robust platform for cancer imaging and therapy.
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Overcoming obstacles in the tumor microenvironment: Recent advancements in nanoparticle delivery for cancer theranostics.
TL;DR: Recent advances in cancer nanomedicine exploiting both nanoparticle design and tumor microenvironment modification are highlighted; and a critical perspective on the future development of nanomedICine delivery in oncology is provided.
References
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Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
(CdSe)ZnS Core-Shell Quantum Dots - Synthesis and Characterization of a Size Series of Highly Luminescent Nanocrystallites
B. O. Dabbousi,Javier Rodríguez-Viejo,F. V. Mikulec,Jason Heine,Hedi Mattoussi,R. Ober,K. F. Jensen,‡,§ and,Moungi G. Bawendi +7 more
TL;DR: In this paper, a synthesis of highly luminescent (CdSe)ZnS composite quantum dots with CdSe cores ranging in diameter from 23 to 55 A was reported.
Journal ArticleDOI
Cancer nanotechnology: opportunities and challenges.
TL;DR: Nanotechnology is a multidisciplinary field, which covers a vast and diverse array of devices derived from engineering, biology, physics and chemistry that can provide essential breakthroughs in the fight against cancer.
Journal ArticleDOI
Nanoparticle therapeutics: an emerging treatment modality for cancer
TL;DR: The features of nanoparticle therapeutics that distinguish them from previous anticancer therapies are highlighted, and how these features provide the potential for therapeutic effects that are not achievable with other modalities are described.
Journal ArticleDOI
Renal clearance of quantum dots.
Hak Soo Choi,Wenhao Liu,Preeti Misra,Eiichi Tanaka,John P. Zimmer,Binil Itty Ipe,Moungi G. Bawendi,John V. Frangioni,John V. Frangioni +8 more
TL;DR: This study has precisely defined the requirements for renal filtration and urinary excretion of inorganic, metal-containing nanoparticles and provides a foundation for the design and development of biologically targeted nanoparticles for biomedical applications.