Renal Physiology of Pregnancy
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Cites background from "Renal Physiology of Pregnancy"
...Progesterone is a potent aldosterone antagonist that acts on the mineralocorticoid receptor to prevent sodium retention(36) and to protect against hypokalemia.(7) The importance of aldosterone is evident in preeclampsia in which plasma volume is reduced and aldosterone concentrations are low....
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...This results in decreases in serum creatinine, urea, and uric acid values.(7)...
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...In the second and third trimesters, there is an increase in exchangeable sodium of ≈500 mEq (≈20 mmol/wk)(34) and a net gain of ≈1000 mg.(7) Furthermore, during pregnancy, relaxin stimulates increased vasopressin secretion and drinking, resulting in increased water retention....
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References
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"Renal Physiology of Pregnancy" refers background in this paper
...Chapman and colleagues documented early rises in GFR and kidney blood flow by inulin and paminohippurate clearances in association with systemic and kidney vasodilation in a series of 10 pregnant women.(25) A series of studies suggests an overall progressive increase in GFR approximating 40% to 50% with peak increases sustained at term in uncomplicated pregnancies....
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308 citations
"Renal Physiology of Pregnancy" refers background in this paper
...A series of studies suggests an overall progressive increase in GFR approximating 40% to 50% with peak increases sustained at term in uncomplicated pregnancies.(26,27) Hyperfiltration has been shown to continue at levels 20% above normal at postpartum week 2(28) and resolve by 1 month postpartum....
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261 citations
"Renal Physiology of Pregnancy" refers background in this paper
...Glomerular filtration rate (GFR) increases 50% and renal plasma flow (RPF) increases up to 80% as compared with nonpregnant levels.(1) Tubular function and handling of water and electrolytes are altered, leading to mild increases in proteinuria, glucosuria, lower serum osmolality, and reductions in serum sodium levels....
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