Renal Transplantation After Ex Vivo Normothermic Perfusion: The First Clinical Study
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TLDR
The preliminary data suggests that EVNP offers promise as a new technique of kidney preservation and demonstrates that this technique is both feasible and safe in renal transplantation.About:
This article is published in American Journal of Transplantation.The article was published on 2013-05-01 and is currently open access. It has received 254 citations till now. The article focuses on the topics: Transplantation & Cold storage.read more
Citations
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Journal ArticleDOI
In situ normothermic regional perfusion for controlled donation after circulatory death--the United Kingdom experience.
Gabriel C. Oniscu,Lucy V. Randle,Paolo Muiesan,Andrew J. Butler,Ian Currie,M. T. P. R. Perera,John Forsythe,Christopher J.E. Watson +7 more
TL;DR: A period of normothermic regional perfusion in DCD donation facilitates organ recovery and may improve short‐term outcomes.
Journal ArticleDOI
Donation after circulatory death: current practices, ongoing challenges, and potential improvements.
TL;DR: Progress in research to identify, prevent, and repair DCD-associated organ retrieval injury should improve utilization of DCD organs and a significant increase in transplantable kidneys could be achieved by extension of the concept of living kidney donation in relation to imminent death of potential DCD donors.
Journal ArticleDOI
Normothermic Perfusion in the Assessment and Preservation of Declined Livers Before Transplantation: Hyperoxia and Vasoplegia-Important Lessons From the First 12 Cases.
Christopher J.E. Watson,Vasilis Kosmoliaptsis,Lucy V. Randle,Alexander Gimson,Rebecca Brais,John R. Klinck,Mazin Hamed,Anastasia Tsyben,Andrew J. Butler +8 more
TL;DR: Avoidance of hyperoxia during perfusion may prevent postreperfusion syndrome and vasoplegia, and monitoring biliary pH, rather than absolute bile production, may be important in determining the likelihood of posttransplant cholangiopathy.
Journal ArticleDOI
Ischemia-Reperfusion Injury Reduces Long Term Renal Graft Survival: Mechanism and Beyond
TL;DR: Clinical evidence and laboratory studies are reviewed, and critical analysis of previous publications indicates that early IRI does contribute to later graft loss through reduction of renal functional mass, graft vascular injury, and chronic hypoxia, as well as subsequent fibrosis.
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Normothermic machine perfusion for the assessment and transplantation of declined human kidneys from donation after circulatory death donors
TL;DR: Ex vivo normothermic machine perfusion provides a unique opportunity to assess the quality of a kidney and determine its suitability for transplantation.
References
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Association between delayed graft function and allograft and patient survival: a systematic review and meta-analysis
TL;DR: The results of this meta-analysis emphasize and quantify the long-term detrimental association between DGF and important graft outcomes like graft survival, acute rejection and renal function.
Journal ArticleDOI
Organ Donation and Utilization in the United States, 1996–2005
Randall S. Sung,J. Galloway,Janet E. Tuttle-Newhall,T. Mone,R. Laeng,Chris E. Freise,Panduranga S. Rao +6 more
TL;DR: Issues directly related to the organ donation process, including donor consent, donor medical suitability, non‐recovery of organs, organs recovered but not transplanted, expanded criteria donors (ECD), and donation after cardiac death (DCD), are discussed.
Journal ArticleDOI
Major effects of delayed graft function and cold ischaemia time on renal allograft survival
Isabel Quiroga,P. McShane,Dicken D. H. Koo,Derek W. R. Gray,Peter J. Friend,Susan V. Fuggle,Christopher R. Darby +6 more
TL;DR: The results of this analysis of well-matched transplant recipients show that CIT and DGF are the most important predictors of poor short and long-term graft survival.
Journal ArticleDOI
A systematic review of kidney transplantation from expanded criteria donors.
TL;DR: ECD kidneys have worse long-term survival than standard criteria donor kidneys and patients younger than 40 years or scheduled for kidney retransplantation should not receive an ECD kidney, based on the available evidence.
Journal ArticleDOI
Organ donation and utilization in the United States, 1999-2008: Special feature
TL;DR: The OPTN/UNOS Living Donor Transplant Committee restructured to enfranchise organ donors and recipients, and to seek their perspectives on living donor transplantation, and numbers of living donors from racial minorities remained unchanged.
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