Journal ArticleDOI
Reoperation directed by carcinoembryonic antigen level: The importance of a thorough preoperative evaluation
Patrick J. O'Dwyer,Cathy Mojzisik,Daniel P. McCabe,William B. Farrar,Larry C. Carey,Edward W. Martin +5 more
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TLDR
Many asymptomatic patients suspected to have recurrent colorectal cancer based on an elevated carcinoembryonic antigen level will be spared unnecessary operation if strict attention is paid to their preoperative evaluation.Abstract:
Summary Many asymptomatic patients suspected to have recurrent colorectal cancer based on an elevated carcinoembryonic antigen level will be spared unnecessary operation if strict attention is paid to their preoperative evaluation. Liver and renal function should be assessed. Unresectable extraabdominal and intraabdominal recurrence or metastases should be excluded. Patients being evaluated for recurrence after curative resection of a rectosigmoid cancer should undergo a bone scan. Having satisfactorily ensured normal results for these investigations, the surgeon should then proceed to search for an intraabdominal source of tumor recurrence.read more
Citations
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Carcinoembryonic Antigen in the Staging and Follow-up of Patients with Colorectal Cancer
TL;DR: In the follow-up of patients undergoing palliative therapy, the CEA level correlates well with response, and CEA is indicative of not only response but may also identify patients with stable disease for whom there is also a demonstrated benefit in survival and symptom relief with combination chemotherapy.
Journal ArticleDOI
Five-year follow-up after radical surgery for colorectal cancer. Results of a prospective randomized trial.
TL;DR: Earlier detection of recurrent colorectal cancer by intensified follow-up does not lead to either significantly increased reresectability or improved 5-year survival.
Journal ArticleDOI
The value of serum carcinoembryonic antigen in predicting recurrent disease following curative resection of colorectal cancer
John L. McCall,Robert B. Black,Caroline A. Rich,John R. Harvey,Robert A. Baker,James McK. Watts,James Toouli +6 more
TL;DR: In this paper, the authors used CCA estimations to facilitate early diagnosis of recurrent disease after treatment for colorectal cancer and found that CEA was the first indicator of recurrent diseases in 58 percent of all patients and in 80 percent of patients with liver metastases.
Journal ArticleDOI
Colon, rectum, and anus.
TL;DR: Adherence to principles of screening, diagnosis, and management have the potential to substantially improve survival in cancer of the colon.
Blood CEA levels for detecting recurrent colorectal cancer (Review)
Brian D Nicholson,Bethany Shinkins,I Pathiraja,Nia Roberts,Tim James,Susan Mallett,Rafael Perera,John N. Primrose,David Mant +8 more
TL;DR: To determine the diagnostic performance of different blood CEA levels in identifying people with colorectal cancer recurrence in order to inform clinical practice, two review authors assessed the quality of all articles independently, discussing any disagreements.
References
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Journal ArticleDOI
The clinical correlation of an autopsy study of recurrent colorectal cancer.
J P Welch,G A Donaldson +1 more
TL;DR: The findings indicate that the presence of squamous cell dysplasia cannot be predicted by the finding of Grade I or II mosaicism or punctation in the DES-exposed female despite the fact that these abnormal colposcopic patterns are associated with Dysplasia in about 10% of cases when encountered in the cervix of the unexposed woman.
Journal ArticleDOI
Results of a 400-patient carcinoembryonic antigen second-look colorectal cancer study.
John P. Minton,James L. Hoehn,David M. Gerber,J. Shelton Horsley,David P. Connolly,Fayiz Salwan,William S. Fletcher,Anatolio B. Cruz,Frank G. Gatchell,Miguel Oviedo,Kenneth K. Meyer,Lasalle D. Leffall,Richard S. Berk,Peter A. Stewart,Susan E. Kurucz +14 more
TL;DR: The highest resectability of recurrent cancer occurred in patients with a CEA level below 11 ng/ml in whom the CEAlevel was determined at intervals of 1 to 2 months.
Journal ArticleDOI
Comparison of computed and conventional whole lung tomography in detecting pulmonary nodules: a prospective radiologic-pathologic study
TL;DR: Whole lung computed tomography was performed on 25 patients with clinical diagnoses including osteogenic sarcoma and 60% of the additional nodules defined by CT and resected proved to be benign granulomas and pleural-based nodes at thoracotomy.
Journal ArticleDOI
CEA-directed second-look surgery in the asymptomatic patient after primary resection of colorectal carcinoma.
TL;DR: A rise in CEA above the baseline established after primary resection proved to be a sensitive indicator of recurrence and prompted reexploration before symptoms developed and early alternative therapy was begun in patients with unresectable recurrences.
Journal ArticleDOI
Carcinoembryonic antigen: clinical and historical aspects.
Edward W. Martin,William E. Kibbey,Loretta Divecchia,Gregg Anderson,Philip Catalano,John P. Minton +5 more
TL;DR: Rectal examination with guaiac determinations, sigmoidoscopy, cytology, barium enema, and a good clinical evaluation remain the primary tools for detecting colorectal disease, but in the high‐risk patient suspicious of developing cancer, CEA determinations as well as colonoscopy are now being used increasingly and provide additional highly valuable tools in the physician's armamentarium.