Repair of strand breaks by homologous recombination.
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Cites background from "Repair of strand breaks by homologo..."
...More complex pathways involve Holliday junction resolution or dissolution (Jasin and Rothstein 2013; see also Bizard and Hickson 2014; Wyatt and West 2014)....
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608 citations
Additional excerpts
...This situation would seem to contrast with the case for sister-directed mitotic DSB repair where the two DSB ends appear to remain together, at least for much of the process (reviewed in Jasin and Rothstein 2013)....
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References
12,865 citations
"Repair of strand breaks by homologo..." refers background in this paper
...Evidence that singlestrand nicks or gaps are likewise repaired by HR in mammalian cells comes not only from studies with drugs like camptothecin but also from the use of site-specific nickases, such as meganucleases (Davis and Maizels 2011), zinc finger nucleases (Kim et al. 2012; Ramirez et al. 2012; Wang et al. 2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al. 2004)....
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...2009; Moscou and Bogdanove 2009) and even more so recently by the discovery of an RNA-guided nuclease in bacterial adaptive immunity termed CRISPR/Cas9 (Gasiunas et al. 2012; Jinek et al. 2012)....
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...Nuclease design was greatly facilitated by the discovery of the simple DNA recognition code of TAL effector proteins from pathogenic bacteria, which invade plants (Boch et al. 2009; Moscou and Bogdanove 2009) and even more so recently by the discovery of an RNA-guided nuclease in bacterial adaptive immunity termed CRISPR/Cas9 (Gasiunas et al. 2012; Jinek et al. 2012)....
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...…DNA recognition code of TAL effector proteins from pathogenic bacteria, which invade plants (Boch et al. 2009; Moscou and Bogdanove 2009) and even more so recently by the discovery of an RNA-guided nuclease in bacterial adaptive immunity termed CRISPR/Cas9 (Gasiunas et al. 2012; Jinek et al. 2012)....
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12,265 citations
10,746 citations
"Repair of strand breaks by homologo..." refers background in this paper
...…drugs like camptothecin but also from the use of site-specific nickases, such as meganucleases (Davis and Maizels 2011), zinc finger nucleases (Kim et al. 2012; Ramirez et al. 2012; Wang et al. 2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al. 2004)....
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...Evidence that singlestrand nicks or gaps are likewise repaired by HR in mammalian cells comes not only from studies with drugs like camptothecin but also from the use of site-specific nickases, such as meganucleases (Davis and Maizels 2011), zinc finger nucleases (Kim et al. 2012; Ramirez et al. 2012; Wang et al. 2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al. 2004)....
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...Nuclease design was greatly facilitated by the discovery of the simple DNA recognition code of TAL effector proteins from pathogenic bacteria, which invade plants (Boch et al. 2009; Moscou and Bogdanove 2009) and even more so recently by the discovery of an RNA-guided nuclease in bacterial adaptive immunity termed CRISPR/Cas9 (Gasiunas et al. 2012; Jinek et al. 2012)....
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8,197 citations
"Repair of strand breaks by homologo..." refers background in this paper
...…drugs like camptothecin but also from the use of site-specific nickases, such as meganucleases (Davis and Maizels 2011), zinc finger nucleases (Kim et al. 2012; Ramirez et al. 2012; Wang et al. 2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al. 2004)....
[...]
...Evidence that singlestrand nicks or gaps are likewise repaired by HR in mammalian cells comes not only from studies with drugs like camptothecin but also from the use of site-specific nickases, such as meganucleases (Davis and Maizels 2011), zinc finger nucleases (Kim et al. 2012; Ramirez et al. 2012; Wang et al. 2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al. 2004)....
[...]
...Nuclease design was greatly facilitated by the discovery of the simple DNA recognition code of TAL effector proteins from pathogenic bacteria, which invade plants (Boch et al. 2009; Moscou and Bogdanove 2009) and even more so recently by the discovery of an RNA-guided nuclease in bacterial adaptive immunity termed CRISPR/Cas9 (Gasiunas et al. 2012; Jinek et al. 2012)....
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...2012), CRISPR/Cas9 (Cong et al. 2013; Mali et al. 2013), and corrupted Rag proteins (Lee et al....
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2,897 citations
"Repair of strand breaks by homologo..." refers background in this paper
...These “designer” nucleases are being used for genome engineering in a variety of organisms in addition to mammalian cells, including zebrafish (Hwang et al. 2013) and livestock (Carlson et al. 2012)....
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...These “designer” nucleases are being used for genome engineering in a variety of organisms in addition to mammalian cells, including zebrafish (Hwang et al. 2013) and livestock (Carlson et al....
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