Repeated Δ9-tetrahydrocannabinol (THC) vapor inhalation during adolescence: Sex differences inacute thermoregulatory tolerance and in feeding during adulthood
Citations
44 citations
Cites background from "Repeated Δ9-tetrahydrocannabinol (T..."
...Our recent study in adult rats showed tolerance to the hypothermic and antinociceptive responses to THC after twice (female) or three times (male or female) daily inhalation (Nguyen et al., 2018)....
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37 citations
Cites background or methods from "Repeated Δ9-tetrahydrocannabinol (T..."
...Rats were administered a conjugate vaccine (Oxy-TT; N=12) or the tetanus toxoid carrier protein only (TT; N= 10) on Weeks 0, 2, and 4, adapted from a vaccination protocol previously reported (Nguyen et al., 2018c); see Supplemental Methods for full details....
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...…however, the key result is that THC was equally effective at reducing the IVSA of oxycodone in each of the adolescent-treatment groups, suggesting no lasting alteration of CB1 function (Nguyen et al., 2018a, 2018b) that was relevant to the interaction of THC with the rewarding effects of oxycodone....
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...We also used two strategies that reduce the oxycodone penetration to the brain for each response, anti-oxycodone vaccination (Nguyen et al., 2018c) and per-infusion dose reduction, thereby requiring increased behavioral output; parallel effects of THC on IVSA would be incompatible with an inference…...
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...…mg/kg, s.c.), THC (5,10 mg/kg, i.p.) or the combination were conducted in a group of adult male (N= 6; 48 wks of age, 665.2, SD 76.2 g) and female (N=8; 48 wks of age, 310.5, SD 44.3 g) Wistar rats that were previously used in experiments of chronic vapor inhalation of THC (Nguyen et al., 2018b)....
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...First, we used an anti-oxycodone vaccine strategy which results in about a 50% reduction in brain levels of oxycodone after a given dose (Nguyen et al., 2018c) and increases the intravenous self-administration of oxycodone under easy access conditions (i.e., a fixed-ratio 1 response contingency),…...
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28 citations
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Cites methods from "Repeated Δ9-tetrahydrocannabinol (T..."
...The training dose (0.15 mg/kg/infusion; ~0.1 ml/infusion) was selected from prior oxycodone self-administration studies (Nguyen et al, 2018; Wade et al, 2015)....
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References
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"Repeated Δ9-tetrahydrocannabinol (T..." refers background in this paper
...This shows the potential risks of repeated THC exposure, however, prior investigations have primarily employed the injected route of administration (Cha et al, 2007; Ellgren et al, 2007; Rubino et al, 2008; Winsauer et al, 2011) which may not match the human condition very well....
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...…THC. Repeated treatment of adolescent rats with THC by injection results in observable lasting effects in adulthood including decreased bodyweight (Rubino et al, 2008), impaired spatial working memory (Rubino et al, 2009), increased heroin self-administration (Ellgren et al, 2007), increased…...
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...Prior studies have identified decreased bodyweight (Rubino et al, 2008), impaired spatial working memory (Rubino et al, 2009), and greater sensitivity to THC on a learning task (Winsauer et al, 2011) in the wake of repeated adolescent THC exposure....
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274 citations
"Repeated Δ9-tetrahydrocannabinol (T..." refers background in this paper
...This shows the potential risks of repeated THC exposure, however, prior investigations have primarily employed the injected route of administration (Cha et al, 2007; Ellgren et al, 2007; Rubino et al, 2008; Winsauer et al, 2011) which may not match the human condition very well....
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...Another study injected male Long-Evan rats with THC (1.5 mg/kg, i.p.) every third day from PND 28-49 (Ellgren et al, 2007)....
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...…inhalation in the adult rat in terms of tolerance to acute THC exposure, alterations in weight gain and feeding behavior (Sofia and Barry, 1974) and the propensity to self-administer an opioid drug, oxycodone, as has previously been reported for heroin (Ellgren et al, 2007; Stopponi et al, 2014)....
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...…including decreased bodyweight (Rubino et al, 2008), impaired spatial working memory (Rubino et al, 2009), increased heroin self-administration (Ellgren et al, 2007), increased reinstatement of heroin seeking after a pharmacological stressor (Stopponi et al, 2014) and greater sensitivity to…...
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