Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)
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...This instability can contribute to intratumor heterogeneity by providing a pool of mutations upon which selection can act in a given microenvironmental context (Burrell et al., 2013a)....
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...Depletion of these three genes in vitro initiates replication stress and generation of structural CIN and numerical CIN defined by centromeric fluorescence in situ hybridization, resulting in intercellular heterogeneity (Burrell et al., 2013b)....
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...…the genome in a cancer cell can be used to decipher the mutational processes that have been active during its evolutionary history (Helleday et al., 2014), the extent of heterogeneity and its dynamics over time can reveal a tumor’s life history (Burrell et al., 2013a; Yates and Campbell, 2012)....
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...…that elevating chromosome missegration rates can be used as a strategy to kill tumor cells or limit tumor development (Janssen et al., 2009; Weaver et al., 2007) and that supplementing cells with nucleosides can reduce the frequency of chromosomal segregation errors (Burrell et al., 2013b)....
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