Reply: Does vitamin C have a pro-oxidant effect?
Ian D. Podmore,Helen R. Griffiths,Karl E. Herbert,Nalini Mistry,Pratibha Mistry,Joseph Lunec +5 more
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Changes in lymphocyte DNA to two established ‘markers’ of oxidative DNA damage after daily supplementation of healthy volunteers with 500 mg vitamin C for six weeks seem to act as both a pro-oxidant and an antioxidant in vivo.Abstract:
Podmore et al reply — In our Scientific Correspondence
1 we reported changes in lymphocyte DNA to two established ‘markers’ of oxidative DNA damage after daily supplementation of healthy volunteers with 500 mg vitamin C for six weeks One marker, 8-oxoadenine, increased, whereas the other, 8-oxoguanine, decreased On this basis, vitamin C seems to act as both a pro-oxidant and an antioxidant in vivo Our contribution has stimulated many comments, most of which were addressed in our original manuscript to Nature, which was shortened for publication at the editors' request The full details are available from us on requestread more
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Does vitamin C act as a pro-oxidant under physiological conditions?
Anitra C. Carr,Balz Frei +1 more
TL;DR: Although the data on protein oxidation in humans are sparse and inconclusive, the available data in animals consistently show an antioxidant role of vitamin C, both in the presence and absence of metal ions.
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Review: When is an antioxidant not an antioxidant? A review of novel actions and reactions of vitamin C.
Tiago L. Duarte,Joseph Lunec +1 more
TL;DR: Evidence from human trials that have attempted an association between vitamin C supplementation and an effect on biomarkers of oxidative DNA damage is summarized and recent evidence that vitamin C is able to modulate gene expression and cellular function is reviewed, with a particular interest in cell differentiation.
Journal ArticleDOI
Novel repair action of vitamin C upon in vivo oxidative DNA damage
Marcus S. Cooke,Mark D. Evans,Ian D. Podmore,Karl E. Herbert,Nalini Mistry,Pratibha Mistry,Peter T. Hickenbotham,Amina Hussieni,Helen R. Griffiths,Joseph Lunec +9 more
TL;DR: The kinetics of 8‐oxo‐2′‐deoxyguanosine removal and processing in vivo are illustrated, for the first time in humans, suggesting a role for vitamin C in the regulation of DNA repair enzymes and thereby demonstrating a non‐scavenging antioxidant effect.
Journal ArticleDOI
Urinary 8-oxo-2'-deoxyguanosine--source, significance and supplements.
TL;DR: It is suggested that nucleotide excision repair and the action of a specific endonuclease may, in addition to the nucleotide pool, contribute significantly to levels of 8-oxodG in the urine.
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Nutraceuticals, vitamins, antioxidants, and minerals in the prevention and treatment of hypertension.
Mark C. Houston,Mark C. Houston +1 more
TL;DR: The expanded scientific roles for nutraceutical supplements will be discussed in relation to the prevention and treatment of essential hypertension with emphasis on mechanisms of action and clinical integration with drug therapy as indicated based on the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure.
References
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Vitamin C exhibits pro-oxidant properties
Ian D. Podmore,Helen R. Griffiths,Karl E. Herbert,Nalini Mistry,Pratibha Mistry,Joseph Lunec +5 more
TL;DR: It is reported here that vitamin C administered as a dietary supplement to healthy humans exhibits a pro-oxidant, as well as an antioxidant, effect in vivo.