Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice.
TL;DR: The results indicate that the abnormal sperm quality in ICR mice caused by PS-MPS exposure is closely related to the Nrf2/HO-1/NF-κB pathway.
About: This article is published in Journal of Hazardous Materials.The article was published on 2021-03-05. It has received 144 citations till now. The article focuses on the topics: Sperm & Spermatogenesis.
Citations
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TL;DR: It is demonstrated that PS-MPs induced male reproductive dysfunctions in mice, which provided new insights into the toxicity of MPs in mammals.
211 citations
TL;DR: In this paper, the toxic effects of microplastics in fish through various indicators were examined, including bioaccumulation, hematological parameters, antioxidant responses, immune responses, and neurotoxicity in relation to MP exposure.
147 citations
TL;DR: Compared with virgin MPs and PAEs alone, PAE-contaminated MPs induced enhanced reproductive toxicities manifested by greater alterations in sperm physiology and spermatogenesis, which provide valuable insights into the mechanism of combined toxicity of MPs and other pollutants.
68 citations
TL;DR: In this article , the reproductive toxicity of polystyrene MPs (PS-MPs) in female mice was evaluated after continued exposure for 35 days, and the results showed that PS-MP exposure induced the inflammation of ovaries and reduced the quality of oocytes in mice, which provided a basis for studying the reproductive toxic mechanism of PSMPs in female mammals.
53 citations
TL;DR: In this paper, the authors investigated the effect of two size polystyrene microplastics (PS-MPs, 1-10µm and 50-100 µm) on the growth of anterior tibial (TA) muscle and repair after injury in mice.
49 citations
References
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TL;DR: This review critically evaluates the current literature on the presence, behaviour and fate of microplastics in freshwater and terrestrial environments and, where appropriate, draws on relevant studies from other fields including nanotechnology, agriculture and waste management.
1,864 citations
TL;DR: The uptake and tissue accumulation of polystyrene microplastics in zebrafish were detected, and the toxic effects in liver were investigated, showing that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver.
Abstract: Microplastics have become emerging contaminants, causing widespread concern about their potential toxic effects. In this study, the uptake and tissue accumulation of polystyrene microplastics (PS-MPs) in zebrafish were detected, and the toxic effects in liver were investigated. The results showed that after 7 days of exposure, 5 μm diameter MPs accumulated in fish gills, liver, and gut, while 20 μm diameter MPs accumulated only in fish gills and gut. Histopathological analysis showed that both 5 μm and 70 nm PS-MPs caused inflammation and lipid accumulation in fish liver. PS-MPs also induced significantly increased activities of superoxide dismutase and catalase, indicating that oxidative stress was induced after treatment with MPs. In addition, metabolomic analysis suggested that exposure to MPs induced alterations of metabolic profiles in fish liver and disturbed the lipid and energy metabolism. These findings provide new insights into the toxic effects of MPs on fish.
1,244 citations
TL;DR: In this paper microplastics, defined as plastic particles smaller than 5 mm, are ubiquitous in natural environments and they are increasingly polluting aqueous, terrestrial, and airborne environments.
Abstract: Microplastics, defined as plastic particles smaller than 5 mm, are ubiquitous in natural environments. They are increasingly polluting aqueous, terrestrial, and airborne environments, and there hav...
741 citations
TL;DR: Investigation of tissue distribution, accumulation, and tissue-specific health risk of MPs in mice revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure, and provided new evidence for the adverse consequences of MPs.
Abstract: Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5 μm and 20 μm) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs.
675 citations
TL;DR: NF-kappaB p65 subunit repressed the Nrf2-antioxidant response element (ARE) pathway at transcriptional level and might provide a new insight into a possible role of NF- kappaB in suppressing the expression of anti-inflammatory or anti-tumor genes.
560 citations