Journal ArticleDOI
Residual polyvinyl alcohol associated with poly (D,L-lactide-co-glycolide) nanoparticles affects their physical properties and cellular uptake.
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The residual PVA associated with nanoparticles is an important formulation parameter that can be used to modulate the pharmaceutical properties of PLGA nanoparticles.About:
This article is published in Journal of Controlled Release.The article was published on 2002-07-18. It has received 915 citations till now. The article focuses on the topics: PLGA & Polyvinyl alcohol.read more
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Journal ArticleDOI
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
Jayanth Panyam,Vinod Labhasetwar +1 more
TL;DR: Based on the above mechanism, various potential applications of nanoparticles for delivery of therapeutic agents to the cells and tissue are discussed.
Journal ArticleDOI
PEGylation as a strategy for improving nanoparticle-based drug and gene delivery
TL;DR: The history of the development of PEGylated nanoparticle formulations for systemic administration is described, including how factors such as PEG molecular weight, PEG surface density, nanoparticle core properties, and repeated administration impact circulation time.
Journal ArticleDOI
Freeze-drying of nanoparticles: formulation, process and storage considerations.
TL;DR: The most important parameters that influence the success of freeze-drying of these fragile systems are discussed, and an overview of nanoparticles freeze-Drying process and formulation strategies are provided with a focus on the impact of formulation and process on particle stability.
Journal ArticleDOI
PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect
Sarbari Acharya,Sanjeeb K. Sahoo +1 more
TL;DR: Drug-loaded nanoparticles extravasate through the tumour vasculature, delivering their payload into the cells by the enhanced permeability and retention (EPR) effect, thereby increasing their therapeutic effect.
Journal ArticleDOI
Methods for the preparation and manufacture of polymeric nanoparticles.
TL;DR: This review summarizes the different methods of preparation of polymer nanoparticles including nanospheres and nanocapsules and presents the most recent innovations and progresses obtained over the last decade.
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Journal Article
Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
Journal ArticleDOI
Biodegradable long-circulating polymeric nanospheres
Ruxandra Gref,Yoshiharu Minamitake,Maria Teresa Peracchia,Vladimir S. Trubetskoy,Vladimir P. Torchilin,Robert Langer +5 more
TL;DR: Monodisperse biodegradable nanospheres were developed from amphiphilic copolymers composed of two biocompatible blocks and exhibited dramatically increased blood circulation times and reduced liver accumulation in mice.
Journal ArticleDOI
The manufacturing techniques of various drug loaded biodegradable poly(lactide-co-glycolide) (PLGA) devices.
TL;DR: This review discusses the various traditional and novel techniques (such as in situ microencapsulation) of preparing various drug loaded PLGA devices, with emphasis on preparing microparticles.
Journal ArticleDOI
Rapid endo-lysosomal escape of poly(dl-lactide-co-glycolide) nanoparticles: implications for drug and gene delivery
TL;DR: The mechanism of rapid escape is by selective reversal of the surface charge of NPs (from anionic to cationic) in the acidic endolysosomal compartment, which causes the NPs to interact with the endo‐lysosomal membrane and escape into the cytosol.
Journal ArticleDOI
The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent.
TL;DR: Caco-2 cells are used as an in vitro model for gastrointestinal uptake, and therefore the results obtained in these studies could be of significant importance in optimizing the microparticle-based oral drug delivery systems.
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Biodegradable nanoparticles for drug and gene delivery to cells and tissue
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