Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents
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Additional excerpts
...Aspartate aminotransferase 50 (23) 4 (2) 31 (14) 3 (1) 38 (20) 3 (2)...
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...Pyrexia 45 (20) 4 (2) 35 (16) 2 (1) 27 (14) 1 (1)...
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...Insufficient data to assess response¶ 9 (8) 2 (2) 21 (20)...
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Cites background from "Resistance to BRAF Inhibition in BR..."
...The inhibition of PI3K or AKT or the use of hypomethylating agents that secondarily block AKT signaling can overcome this mechanism of resistance in vitro.(78) Understanding of mechanisms of induction of parallel signaling is needed to guide development of combination therapies....
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References
6,797 citations
6,773 citations
"Resistance to BRAF Inhibition in BR..." refers background in this paper
...Vemurafenib achieved a response rate of 48% to 67% in theBRAFmelanoma (11, 12)....
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3,399 citations
"Resistance to BRAF Inhibition in BR..." refers background in this paper
...Vemurafenib achieved a response rate of 48% to 67% in theBRAFmelanoma (11, 12)....
[...]
2,588 citations
2,065 citations
"Resistance to BRAF Inhibition in BR..." refers background in this paper
...Several studies have investigated mechanisms of resistance to selective BRAF inhibitors in melanoma (14-16)....
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