Resolution of inflammation: an integrated view
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TLDR
This review integrates the key molecular and cellular mechanisms of resolution and describes how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance.Abstract:
Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.read more
Citations
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Microglial M1/M2 polarization and metabolic states.
TL;DR: The polarization states of microglia and their relationship to mitochondrial metabolism are examined and a role of metabolic reprogramming in the regulation of the innate inflammatory response is suggested.
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Inflammation, fracture and bone repair
Florence Loi,Luis A. Córdova,Luis A. Córdova,Jukka Pajarinen,Tzuhua Lin,Zhenyu Yao,Stuart B. Goodman +6 more
TL;DR: In this review, a comprehensive summary of the literature related to inflammation and bone repair is provided, placing special emphasis on the underlying cellular and molecular mechanisms, and potential interventions that can favorably modulate the outcome of clinical conditions that involve bone repair.
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Low-grade inflammation, diet composition and health: current research evidence and its translation
Anne Marie Minihane,Sophie Vinoy,Wendy R. Russell,Athanasia Baka,Helen M. Roche,Kieran Tuohy,Jessica L. Teeling,Ellen E. Blaak,Michael Fenech,David Vauzour,Harry J. McArdle,Bas Kremer,Luc Sterkman,Katerina Vafeiadou,M. Massi Benedetti,Christine M. Williams,Philip C. Calder +16 more
TL;DR: The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch and is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled ‘Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies’.
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Inflammation following acute myocardial infarction: Multiple players, dynamic roles, and novel therapeutic opportunities.
Sang Bing Ong,Sauri Hernández-Reséndiz,Gustavo E. Crespo-Avilan,Regina T. Mukhametshina,Xiu Yi Kwek,Hector A. Cabrera-Fuentes,Derek J. Hausenloy +6 more
TL;DR: An overview of the multiple players (and their dynamic roles) involved in the complex inflammatory response to AMI and subsequent LV remodeling is provided, and future opportunities for targeting inflammation as a therapeutic strategy for limiting MI size, preventing adverse left ventricular remodeling, and reducing heart failure in AMI patients are highlighted.
Journal ArticleDOI
Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype
Michael Horckmans,Larisa Ring,Johan Duchene,Donato Santovito,Donato Santovito,Maximilian J. Schloss,Maik Drechsler,Christian Weber,Oliver Soehnlein,Sabine Steffens +9 more
TL;DR: Neutrophils are crucially involved in cardiac repair after MI by polarizing macrophages towards a reparative phenotype, andTherapeutic strategies to reduce acute neutrophil-driven inflammation after MI should be carefully balanced as they might interfere with the healing response and cardiac remodelling.
References
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