Resolution of inflammation: the beginning programs the end.
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4,832 citations
Cites background from "Resolution of inflammation: the beg..."
...A successful acute inflammatory response results in the elimination of the infectious agents followed by a resolution and repair phase, which is mediated mainly by tissue-resident and recruited macrophage...
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Cites background from "Resolution of inflammation: the beg..."
...Studies over the past four decades have also defined the eicosanoids (and other products of arachidonic acid metabolism) as key inter- and intracellular lipid signalling molecules, which are primarily involved in mediating or resolving inflammatory response...
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2,197 citations
Cites background from "Resolution of inflammation: the beg..."
...Inflammation resolution processes that rectify tissue homeostasis include reduction or cessation of tissue infiltration by neutrophils and apoptosis of spent neutrophils, counter-regulation of chemokines and cytokines, macrophage transformation from classically to alternatively activated cells, and initiation of healing [79, 80]....
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2,130 citations
References
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"Resolution of inflammation: the beg..." refers background in this paper
...We argue here that events occurring early in acute inflammation engage an active and coordinated 'resolution program' involving a switch to local production of specialized intercellular messengers, programmed leukocyte death by apoptosis and subsequent clearance of dying cells by phagocytes that then leave the inflamed site through lymphatic...
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2,161 citations