Responses of Medicinal and Aromatic Plants to Engineered Nanoparticles
TL;DR: This paper provides a comprehensive overview of the beneficial and adverse effects of metal-, metalloid-, and carbon-based nanoparticles on the germination, growth, and biochemical characteristics of a wide range of medicinal and aromatic plants, including the corresponding mechanisms of action.
Abstract: Medicinal and aromatic plants have been used by mankind since ancient times. This is primarily due to their healing effects associated with their specific secondary metabolites (some of which are also used as drugs in modern medicine), or their structures, served as a basis for the development of new effective synthetic drugs. One way to increase the production of these secondary metabolites is to use nanoparticles that act as elicitors. However, depending on the specific particle size, composition, concentration, and route of application, nanoparticles may have several other benefits on medicinal and aromatic plants (e.g., increased plant growth, improved photosynthesis, and overall performance). On the other hand, particularly at applications of high concentrations, they are able to damage plants mechanically, adversely affect morphological and biochemical characteristics of plants, and show cytotoxic and genotoxic effects. This paper provides a comprehensive overview of the beneficial and adverse effects of metal-, metalloid-, and carbon-based nanoparticles on the germination, growth, and biochemical characteristics of a wide range of medicinal and aromatic plants, including the corresponding mechanisms of action. The positive impact of nanopriming and application of nanosized fertilizers on medicinal and aromatic plants is emphasized. Special attention is paid to the effects of various nanoparticles on the production of valuable secondary metabolites in these plants cultivated in hydroponic systems, soil, hairy root, or in vitro cultures. The beneficial impact of nanoparticles on the alleviation of abiotic stresses in medicinal and aromatic plants is also discussed.
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TL;DR: An overview of the role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs is presented in this article.
Abstract: An overview is presented of the well-established role of alkaloids in drug discovery, the application of more sustainable chemicals, and biological approaches, and the implementation of information systems to address the current challenges faced in meeting global disease needs. The necessity for a new international paradigm for natural product discovery and development for the treatment of multidrug resistant organisms, and rare and neglected tropical diseases in the era of the Fourth Industrial Revolution and the Quintuple Helix is discussed.
21 citations
TL;DR: Nanotechnology offers new tools for enhancing the biomass and metabolism of medicinal plant and the low yield and active ingredient content of medicinal plants is a challenge.
Abstract: The low yield and active ingredient content of medicinal plants is always a challenge. Nanotechnology offers new tools for enhancing the biomass and metabolism of medicinal plant. In the present...
6 citations
TL;DR: In this paper, a series of 12 nature-inspired 3,4,5-trimethoxycinnamates were tested for their ability to inhibit AChE and butyrylcholinesterase (BChE) in vitro; the selectivity index was also determined.
Abstract: A series of twelve nature-inspired 3,4,5-trimethoxycinnamates were prepared and characterized. All compounds, including the starting 3,4,5-trimethoxycinnamic acid, were tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) in vitro; the selectivity index (SI) was also determined. 2-Fluororophenyl (2E)-3-(3,4,5-trimethoxyphenyl)-prop-2-enoate demonstrated the highest SI (1.71) in favor of BChE inhibition. 2-Chlorophenyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate showed the highest AChE-inhibiting (IC50 = 46.18 µM) as well as BChE-inhibiting (IC50 = 32.46 µM) activity with an SI of 1.42. The mechanism of action of the most potent compound was determined by the Lineweaver–Burk plot as a mixed type of inhibition. An in vitro cell viability assay confirmed the insignificant cytotoxicity of the discussed compounds on the two cell lines. Trends between structure, physicochemical properties and activity were discussed.
5 citations
TL;DR: In this article , the influence of a chitin and abiotic (copper nanoparticle) elicitor on ZM under in vitro and greenhouse conditions was analyzed, with the aim of increasing the bioactive compounds production.
4 citations
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TL;DR: The role of Si in conferring resistance to mutiple stresses is described and genetic modification of the root ability to take up Si has been proposed to obtain plants resistant to multiple stresses.
Abstract: Although silicon (Si) has not been recognized as an essential element for plant growth, the beneficial effects of Si have been observed in a wide variety of plant species. The beneficial effects of Si are usually expressed more clearly in Si-accumulating plants under various abiotic and biotic stress conditions. Silicon is effective in controlling various pests and diseases caused by both fungi and bacteria in different plant species. Silicon also exerts alleviative effects on various abiotic stresses including salt stress, metal toxicity, drought stress, radiation damage, nutrient imbalance, high temperature, freezing and so on. These beneficial effects are mainly attributed to the high accumulation of silica on the tissue stirface although other mechanisms have also been proposed. To obtain plants resistant to multiple stresses, genetic modification of the root ability to take up Si has been proposed. In this review, the role of Si in conferring resistance to mutiple stresses is described.
1,146 citations
TL;DR: The key mechanisms of Si-mediated alleviation of abiotic stresses in higher plants include: stimulation of antioxidant systems in plants, complexation or co-precipitation of toxic metal ions with Si, immobilization of toxicMetal ions in growth media, uptake processes, and compartmentation of metal ions within plants.
994 citations
TL;DR: The role of herbs and spices in health benefits is discussed in this paper, where the authors consider the use of herbs as a source of antioxidants to combat oxidation in a healthy diet.
Abstract: UNLABELLED Herbs and spices have a traditional history of use, with strong roles in cultural heritage, and in the appreciation of food and its links to health. Demonstrating the benefits of foods by scientific means remains a challenge, particularly when compared with standards applied for assessing pharmaceutical agents. Pharmaceuticals are small-molecular-weight compounds consumed in a purified and concentrated form. Food is eaten in combinations, in relatively large, unmeasured quantities under highly socialised conditions. The real challenge lies not in proving whether foods, such as herbs and spices, have health benefits, but in defining what these benefits are and developing the methods to expose them by scientific means. CULTURAL ASPECTS The place of herbs and spices in the diet needs to be considered in reviewing health benefits. This includes definitions of the food category and the way in which benefits might be viewed, and therefore researched. Research may focus on identifying bioactive substances in herbs and spices, or on their properties as a whole food, and/or be set in the context of a dietary cuisine. THE ROLE OF HERBS AND SPICES IN HEALTH The antioxidant properties of herbs and spices are of particular interest in view of the impact of oxidative modification of low-density lipoprotein cholesterol in the development of atherosclerosis. There is level III-3 evidence (National Health and Medical Research Council [NHMRC] levels of evidence) that consuming a half to one clove of garlic (or equivalent) daily may have a cholesterol-lowering effect of up to 9%. There is level III-1 evidence that 7.2 g of aged garlic extract has been associated with anticlotting (in-vivo studies), as well as modest reductions in blood pressure (an approximate 5.5% decrease in systolic blood pressure). A range of bioactive compounds in herbs and spices have been studied for anticarcinogenic properties in animals, but the challenge lies in integrating this knowledge to ascertain whether any effects can be observed in humans, and within defined cuisines. Research on the effects of herbs and spices on mental health should distinguish between cognitive decline associated with ageing and the acute effects of psychological and cognitive function. There is level I and II evidence for the effect of some herbal supplements on psychological and cognitive function. There is very limited scientific evidence for the effects of herbs and spices on type 2 diabetes mellitus, with the best evidence being available for the effect of ginseng on glycaemia, albeit based on four studies. More research is required, particularly examining the effects of chronic consumption patterns. With increasing interest in alternatives to non-steroidal anti-inflammatory agents in the management of chronic inflammation, research is emerging on the use of food extracts. There is level II evidence for the use of ginger in ameliorating arthritic knee pain; however, the improvement is modest and the efficacy of ginger treatment is ranked below that of ibuprofen. More definitive research is required. PUBLIC HEALTH AND DIETARY IMPLICATIONS Recommendations for intakes of food in the Australian guide to healthy eating do not yet include suggested intakes of herbs and spices. Future consideration should be given to including more explicit recommendations about their place in a healthy diet. In addition to delivering antioxidant and other properties, herbs and spices can be used in recipes to partially or wholly replace less desirable ingredients such as salt, sugar and added saturated fat in, for example, marinades and dressings, stir-fry dishes, casseroles, soups, curries and Mediterranean-style cooking. Vegetable dishes and vegetarian options may be more appetising when prepared with herbs and spices. FUTURE DIRECTIONS As several metabolic diseases and age-related degenerative disorders are closely associated with oxidative processes in the body, the use of herbs and spices as a source of antioxidants to combat oxidation warrants further attention. Immediate studies should focus on validating the antioxidant capacity of herbs and spices after harvest, as well as testing their effects on markers of oxidation. This will work in parallel with clinical trials that are aiming to establish antioxidants as mediators of disease prevention. From a dietary perspective, the functionality of herbs and spices will be exposed through consideration of their properties as foods. As with most foods, the real benefits of including them in the diet are likely to emerge with a better understanding of the attributes of health that are best supported by food, and in methodological developments addressing the evidence base for their effects. These developments are well underway through evidence-based frameworks for substantiating health claims related to foods. At present, recommendations are warranted to support the consumption of foods rich in bioactive components, such as herbs and spices. With time, we can expect to see a greater body of scientific evidence supporting the benefits of herbs and spices in the overall maintenance of health and protection from disease.
801 citations
01 Jan 2006
TL;DR: There is very limited scientific evidence for the effects of herbs and spices on type 2 diabetes mellitus, with the best evidence being available for the effect of ginseng on glycaemia, albeit based on four studies, and more research is required.
Abstract: Recommendations for intakes fo food in the Australian Guide to Healthy Eating do not yet include suggested intakes of herbs and spices, although several dietary guidelines refer to their benefits. Future consideration should be given to including more explicit recommendations about the place of herbs and spices in a healthy diet
739 citations
TL;DR: Application of molecular biology tools and techniques are facilitating understanding the signaling processes and pathways involved in the SMs production at subcellular, cellular, organ and whole plant systems during in vivo and in vitro growth, with application in metabolic engineering of biosynthetic pathways intermediates.
Abstract: In the growth condition(s) of plants, numerous secondary metabolites (SMs) are produced by them to serve variety of cellular functions essential for physiological processes, and recent increasing evidences have implicated stress and defense response signaling in their production. The type and concentration(s) of secondary molecule(s) produced by a plant are determined by the species, genotype, physiology, developmental stage and environmental factors during growth. This suggests the physiological adaptive responses employed by various plant taxonomic groups in coping with the stress and defensive stimuli. The past recent decades had witnessed renewed interest to study abiotic factors that influence secondary metabolism during in vitro and in vivo growth of plants. Application of molecular biology tools and techniques are facilitating understanding the signaling processes and pathways involved in the SMs production at subcellular, cellular, organ and whole plant systems during in vivo and in vitro growth, with application in metabolic engineering of biosynthetic pathways intermediates.
618 citations