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Open accessJournal ArticleDOI: 10.1002/CNR2.1353

Resveratrol-loaded nanomedicines for cancer applications.

02 Mar 2021-Vol. 4, Iss: 3
Abstract: Background Resveratrol (3, 5, 4' -trihydroxystilbene), a natural polyphenol and phytoalexin, has drawn considerable attention in the past decade due to its wide variety of therapeutic activities such as anticancer, anti-inflammatory, and antioxidant properties. However, its poor water solubility, low chemical stability, and short biological half-life limit its clinical utility. Recent findings Nanoparticles overcome the limitations associated with conventional chemotherapeutic drugs, such as limited availability of drugs to the tumor tissues, high systemic exposures, and consequent toxicity to healthy tissues. This review focuses on the physicochemical properties of resveratrol, the therapeutic potential of resveratrol nano-formulations, and the anticancer activity of resveratrol encapsulated nanoparticles on various malignancies such as skin, breast, prostate, colon, liver, ovarian, and lung cancers (focusing on both in vitro and in vivo studies). Conclusions Nanotechnology approaches have been extensively utilized to achieve higher solubility, improved oral bioavailability, enhanced stability, and controlled release of resveratrol. The resveratrol nanoparticles have markedly enhanced its anticancer activity both in vitro and in vivo, thus considering it as a potential strategy to fight various cancers.

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Topics: Resveratrol (60%)
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Journal ArticleDOI: 10.1016/J.INTIMP.2021.107895
Qi Mu1, Masoud Najafi2Institutions (2)
Abstract: Tumor resistance to therapy modalities is one of the major challenges to the eradication of cancer cells and complete treatment. Tumor includes a wide range of cancer and non-cancer cells that play key roles in the proliferation of cancer cells and suppression of anti-tumor immunity. For overcoming tumor resistance to therapy, it is important to have in-depth knowledge relating to intercellular communications within the tumor microenvironment (TME). TME includes various types of immune cells such as CD4 + T lymphocytes, cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, macrophages, and T regulatory cells (Tregs). Furthermore, some non-immune cells like cancer stem cells (CSCs), mesenchymal stem cells (MSCs), and cancer-associated fibroblasts (CAFs) are involved in the promotion of tumor growth. The interactions between these cells with cancer cells play a key role in tumor growth or inhibition. Resveratrol as a natural agent has shown the ability to modulate the immune system to potentiate anti-tumor immunity and also help to attenuate cancer cells and CSCs resistance. Thus, this review explains how resveratrol can modulate interactions within TME.

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Topics: Cancer stem cell (68%), Tumor microenvironment (65%), Cancer cell (61%) ... show more

2 Citations


Open accessJournal ArticleDOI: 10.3390/MOLECULES26144367
20 Jul 2021-Molecules
Abstract: Resveratrol (RES) has a low bioavailability. This limitation was addressed in an earlier review and several recommendations were offered. A literature search was conducted in order to determine the extent of the research that was conducted in line with these recommendations, along with new developments in this field. Most of the identified studies were pre-clinical and confirmed the heightened activity of RES analogues compared to their parent compound. Although this has provided additional scientific kudos for these compounds and has strengthened their potential to be developed into phytopharmaceutical products, clinical trials designed to confirm this increased activity remain lacking and are warranted.

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1 Citations


Journal ArticleDOI: 10.1007/S12032-021-01548-0
17 Jul 2021-Medical Oncology
Abstract: Oral cancer is a very common tumor worldwide with high incidence and mortality. The treatment of oral cancer involves surgery, radio- and chemotherapy; however, high failure rates and toxicity are noticed. Thus, the search of new drugs aiming a more effective treatment is welcomed. Natural products present chemopreventive and anti-cancer effects. Resveratrol is a naturally occurring antioxidant that contains several health benefits, including anti-inflammatory and antiproliferative activities. This review discusses the different action mechanisms of resveratrol related in the in vitro and in vivo studies using models of oral cancer.

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Topics: Resveratrol (54%), Cancer (53%)

Journal ArticleDOI: 10.1002/PTR.7185
Alexander V. Sirotkin1Institutions (1)
Abstract: The present review summarizes the current knowledge concerning physiological effects of resveratrol (RSV) with emphasis on the RSV action on female reproductive processes. The review outlines provenance, properties, mechanisms of action, physiological and therapeutic actions of RSV on female reproduction and other physiological processes, as well as areas of possible application of R. This review is based on the search for the related full papers indexed in Medline/Pubmed, Web of Science and SCOPUS databases between the year 2000 and 2021 according to the criteria of preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews and other related guidelines. The analysis of the available information suggests that RSV has a number of properties which enable its influence on various physiological processes including female reproduction at various regulatory levels via various extra- and intracellular signalling pathways. Despite some contradictions and limitations in the available data, they indicate applicability of both stimulatory and inhibitory effects of RSV for control and influence of various reproductive and non-reproductive processes and treatment of their disorders in phytotherapy, animal production, medicine, biotechnology and assisted reproduction. To establish the clinical efficacy of RSV, further high quality studies are needed.

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Journal ArticleDOI: 10.1016/J.TIFS.2021.08.009
Zhiheng Zhang1, Chao Qiu1, Xiaojing Li2, David Julian McClements3  +4 moreInstitutions (4)
Abstract: Background Plant polyphenols are considered to be one of the most biologically active natural ingredients for the prevention and treatment of chronic diseases due to their antioxidant and anti-inflammatory potential. Despite the protective effects of polyphenols, their low efficiency in delivery systems and poor bioavailability greatly limit their applications in functional foods and medicine. One potential solution is a polyphenol delivery system based on polymerized nanoparticles, which can enhance their absorption in the gastrointestinal tract, improve their bioavailability, and deliver them to target organs. Scope and approach In this paper, the latest research progress of polyphenols loaded on biology-based nanoparticles was reviewed. The methods for preparing different bio-based nanomaterials, the interaction and characterization of nanoparticles in the transfer of polyphenols as a biological activity transport system, and the influence of the digestion and absorption characteristics of polyphenols on different nano-transport systems were also summarized. Key findings and conclusions: Bio-based nanoparticles, as an effective carrier of polyphenols, can improve the water soluble, stability and bioavailability of polyphenols by different biology-based nano-delivery system. In addition, the size of nanomaterials is critical to their various properties and applications. The ability to adjust the dimensions and properties of nanoparticles allows them to construct complexes with different polyphenolic substances, thereby altering their bioavailability and functional properties. Therefore, the polyphenol delivery system based on polymerized nanoparticles is a potential solution to enhance their absorption in the gastrointestinal tract, improve their bioavailability, and deliver them to target organs.

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Topics: Bioavailability (50%)
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169 results found


Klaus Apel1, Heribert Hirt2Institutions (2)
Abstract: Several reactive oxygen species (ROS) are continuously produced in plants as byproducts of aerobic metabolism. Depending on the nature of the ROS species, some are highly toxic and rapidly detoxified by various cellular enzymatic and nonenzymatic mechanisms. Whereas plants are surfeited with mechanisms to combat increased ROS levels during abiotic stress conditions, in other circumstances plants appear to purposefully generate ROS as signaling molecules to control various processes including pathogen defense, programmed cell death, and stomatal behavior. This review describes the mechanisms of ROS generation and removal in plants during development and under biotic and abiotic stress conditions. New insights into the complexity and roles that ROS play in plants have come from genetic analyses of ROS detoxifying and signaling mutants. Considering recent ROS-induced genome-wide expression analyses, the possible functions and mechanisms for ROS sensing and signaling in plants are compared with those in animals and yeast.

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Topics: Abiotic stress (51%), Oxidative stress (51%)

8,735 Citations


Journal ArticleDOI: 10.1126/SCIENCE.275.5297.218
Mei-Shiang Jang1, Lining Cai1, George Udeani1, Karla Slowing2  +8 moreInstitutions (2)
10 Jan 1997-Science
Abstract: Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Topics: Resveratrol (62%), Piceid (53%), Anticarcinogen (51%) ... show more

4,598 Citations


Journal ArticleDOI: 10.1038/NRD2060
Joseph A. Baur1, David A. Sinclair1Institutions (1)
Abstract: Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.

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Topics: Resveratrol (58%), Sirtuin (52%)

3,254 Citations


Open accessJournal ArticleDOI: 10.1016/J.CUB.2014.03.034
Michael Schieber1, Navdeep S. Chandel1Institutions (1)
19 May 2014-Current Biology
Abstract: Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of pathologies. However, elevated ROS also act as signaling molecules in the maintenance of physiological functions — a process termed redox biology. In this review we discuss the two faces of ROS — redox biology and oxidative stress — and their contribution to both physiological and pathological conditions. Redox biology involves a small increase in ROS levels that activates signaling pathways to initiate biological processes, while oxidative stress denotes high levels of ROS that result in damage to DNA, protein or lipids. Thus, the response to ROS displays hormesis, given that the opposite effect is observed at low levels compared with that seen at high levels. Here, we argue that redox biology, rather than oxidative stress, underlies physiological and pathological conditions.

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Topics: Oxidative stress (61%), DNA damage (51%), Hormesis (51%)

3,108 Citations


Book ChapterDOI: 10.1007/978-1-4614-5647-6_1
Jiemin Ma1, Ahmedin Jemal1Institutions (1)
01 Jan 2013-
Abstract: Among U.S. women, breast cancer is the most commonly diagnosed cancer (excluding skin cancers) and the second leading cause of cancer death, following lung cancer. In 2012, an estimated 226,870 new cases of invasive breast cancer and 39,510 breast cancer deaths are expected to occur among U.S. women. Breast cancer rates vary largely by race/ethnicity and socioeconomic status (SES), and geographic region. Death rates are higher in African American women than in whites, despite their lower incidence rates. Historically, breast cancer was recognized as a disease of western countries. However, over the past 20 years, breast cancer incidence and mortality rates have been increasing rapidly in economically less developed regions. According to 2008 GLOBOCAN estimates, half of the new worldwide breast cancer cases (1.38 million) and 60 % of the breast cancer deaths (458,000) occurred in developing countries. This chapter reviews breast cancer incidence and mortality patterns among women in the U.S. and worldwide, and the possible explanations for these patterns.

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Topics: Breast cancer (73%), Cancer (65%), Mortality rate (54%)

2,748 Citations


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