Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants
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1,544 citations
Cites background from "Ret rescues mitochondrial morpholog..."
...Constitutively active Ret, the receptor for glia-cell-linedderived neurotrophic factor, also recues only PINK1-KO flies, restoring the mitochondrial deficits seen in this model (Klein et al., 2014)....
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424 citations
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101 citations
Cites background from "Ret rescues mitochondrial morpholog..."
...It has been reported that lethality or deficient locomotion is seen in Drosophila in which glycolytic enzymes have been knocked down in glia but not in neurons, suggesting that glial glycolysis in the brain is important for survival and normal locomotor behavior [97]....
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...GDNF and its signaling receptor, Ret, rescues PINK1 deficiencyinduced muscle degeneration, mitochondrial disintegration, and ATP content in Drosophila [121]....
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94 citations
Cites background from "Ret rescues mitochondrial morpholog..."
...Co-expressing Drosophila Ret with the MEN2B mutation (Met918Thr) in the Drosophila indirect flight muscle rescued the mitochondrial morphology and muscle degeneration phenotype in PINK1 lossof-function mutant flies [214]....
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...In addition, MEN2B expression rescued the oxygen consumption in PINK1 knock-down SH-SY5Y cells and also the reduced ATP levels and complex I activity in thorax extracts from PINK1 deficient Drosophila [214]....
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...Neither carbonyl cyanide m-chlorophenyl hydrazone (CCCP) induced parkin recruitment to mitochondria, nor mitophagy in parkin overexpressing SH-SY5Y cells, was prevented by MEN2B overexpression or GDNF/GFRa1 stimulation [214]....
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...Expressing the Drosophila MEN2B protein in flies also prevented the mitochondrial morphological alterations in Drosophila PINK1-deficient DA neurons and in mammalian SH-SY5Y cells....
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...Using the Drosophila eye as a genetic screening tool, DJ-1 and Ret were found to genetically interact and to specifically activate the Ras/MAPK, but not the PI3K/Akt signaling cascade [193]....
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References
4,705 citations
"Ret rescues mitochondrial morpholog..." refers background in this paper
...The first indications of a role for mitochondria came with the discovery that the toxin 1-methyl-4-phenyl-1,2,3,4-tetrahydropyridine (MPTP) causes Parkinsonism in humans and animal models (Burns et al, 1983; Langston et al, 1983)....
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3,474 citations
"Ret rescues mitochondrial morpholog..." refers background in this paper
...Several other mitochondrial toxins, including paraquat and rotenone, generating either mitochondrial reactive oxygen species (ROS) or specifically inhibiting complex I, have been linked to PD in epidemiological studies and animal models (de Lau & Breteler, 2006)....
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3,236 citations
"Ret rescues mitochondrial morpholog..." refers background in this paper
...The neurotrophic factor Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopamine neurons (Lin et al, 1993) and protects nigral dopamine neurons from cell death in rodent and primate toxin-models of PD such as 6-hydroxydopamine (6-OHDA) and MPTP (Kearns & Gash, 1995;…...
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2,404 citations
"Ret rescues mitochondrial morpholog..." refers background in this paper
...The EMBO Journal Vol 33 | No 4 | 2014 341 regulate clearance of damaged mitochondria via mitophagy (Geisler et al, 2010; Narendra et al, 2010; Vives-Bauza et al, 2010), and microtubular transport (Weihofen et al, 2009; Wang et al, 2011)....
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...Parkin-induced mitophagy required the presence of PINK1, as described previously (Geisler et al, 2010; Narendra et al, 2010; Vives-Bauza et al, 2010), but was not impaired in cells silenced for Ret expression (Fig 4H, I, J, N, O)....
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2,379 citations
"Ret rescues mitochondrial morpholog..." refers background in this paper
...The EMBO Journal Vol 33 | No 4 | 2014 341 regulate clearance of damaged mitochondria via mitophagy (Geisler et al, 2010; Narendra et al, 2010; Vives-Bauza et al, 2010), and microtubular transport (Weihofen et al, 2009; Wang et al, 2011)....
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...Parkin-induced mitophagy required the presence of PINK1, as described previously (Geisler et al, 2010; Narendra et al, 2010; Vives-Bauza et al, 2010), but was not impaired in cells silenced for Ret expression (Fig 4H, I, J, N, O)....
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