Rethinking ovarian cancer: recommendations for improving outcomes
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...Terms such as “müllerian” or “pelvic serous carcinoma” are not recommended because they create confusion for patients, physicians, and medical investigators [11]....
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...Identification of BRCA1/2 mutation–positive patients appears to be a lost opportunity, given clear evidence of effective preventative strategies for those patients,(38) in contrast to limited progress in early detection of ovarian cancer(39,40) or improvements in treatment outcomes in advanced disease.(41) Even when genetic testing is performed it usually occurs late in the course of a patient’s disease trajectory, yet our study and others(1,6,9,10,12-16) demonstrate that mutation-positive patients have different treatment responses and survival characteristics compared with mutation-negative patients....
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...Tumour cells typically trigger inflammatory cytokine networks as a means of escaping immune recognition in spite of surrounding inflammatio...
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...Conversely, the detection of high numbers of T regulatory cells, which mediate immune suppression, predicts poor patient surviva...
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"Rethinking ovarian cancer: recommen..." refers background in this paper
...The increased infiltration of lymphocytes in tumour islets predicts significantly longer survival in ovarian cance...
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