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Journal ArticleDOI

Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS).

06 Jul 2021-Reviews on environmental health (Walter de Gruyter GmbH)-
TL;DR: In this article, the authors present a review of the executed to-date scientific studies, examining sensitivity to EMF, are of poor quality to find the link between EMF exposures and sensitivity symptoms of some people.
Abstract: Part of the population considers themselves as sensitive to the man-made electromagnetic radiation (EMF) emitted by powerlines, electric wiring, electric home appliance and the wireless communication devices and networks. Sensitivity is characterized by a broad variety of non-specific symptoms that the sensitive people claim to experience when exposed to EMF. While the experienced symptoms are currently considered as a real life impairment, the factor causing these symptoms remains unclear. So far, scientists were unable to find causality link between symptoms experienced by sensitive persons and the exposures to EMF. However, as presented in this review, the executed to-date scientific studies, examining sensitivity to EMF, are of poor quality to find the link between EMF exposures and sensitivity symptoms of some people. It is logical to consider that the sensitivity to EMF exists but the scientific methodology used to find it is of insufficient quality. It is time to drop out psychology driven provocation studies that ask about feelings-based non-specific symptoms experienced by volunteers under EMF exposure. Such research approach produces only subjective and therefore highly unreliable data that is insufficient to prove, or to disprove, causality link between EHS and EMF. There is a need for a new direction in studying sensitivity to EMF. The basis for it is the notion of a commonly known phenomenon of individual sensitivity, where individuals' responses to EMF depend on the genetic and epigenetic properties of the individual. It is proposed here that new studies, combining provocation approach, where volunteers are exposed to EMF, and high-throughput technologies of transcriptomics and proteomics are used to generate objective data, detecting molecular level biochemical responses of human body to EMF.

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Journal ArticleDOI
TL;DR: There is an urgent need for the WHO to advocate for the national governments to urgently develop a comprehensive and common EHS health policy and for research to generate a reliable scientific evidence on what are the possible cause(s) of EHS.
Abstract: Abstract Electromagnetic hypersensitivity (EHS), known also as an idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) or a microwave sickness, is not considered by the World Health Organization (WHO) as being caused by the exposures to electromagnetic fields (EMF). EHS is not recognized as a disease anywhere in the world. Some studies have roughly estimated that 1–10% of the population might experience some form of EHS. However, because of the lack of diagnostic criteria for EHS, these estimates might be either under- or over-estimates. Because the vast majority of human population is exposed to EMF, the possibility of developing EHS from the EMF is a substantial public health issue that should be dealt with globally, even if the individual risk of developing EHS might be small. The WHO recognizes that the symptoms experienced by the EHS persons might be severe and might significantly hamper everyday life. However, after a broad analysis of international and national documents, there seems to be currently no effort to develop health policies for the dealing with EHS, no matter what causes it. National governments, follow the opinions of the WHO and the EMF safety standards setting organizations, the International Commission on Non-Ionizing Radiation Protection (ICNIRP) and the Institute of Electrical and Electronics Engineers – International Committee on Electromagnetic Safety (IEEE-ICES), are not developing any practical health policy advisories for self-declared EHS sufferers. However, symptoms experienced by the self-declared EHS persons affect their well-being and, according to the Constitution of the WHO, are a health problem. Hence, independently of what causes EHS symptoms, this admitted well-being-impairment should be dealt with globally by developing an uniform health policy. Furthermore, WHO, ICNIRP and IEEE-ICES should be advocating and supporting research that would generate a reliable scientific evidence on what are the possible cause(s) of EHS. Without such research there is not possible to develop diagnostic methods as well as any possible mitigation approaches. There is an urgent need for the WHO to advocate for the national governments to urgently develop a comprehensive and common EHS health policy.

2 citations

Journal ArticleDOI
TL;DR:
Abstract: Abstract Patients’ experiential knowledge is increasingly recognised as valuable for biomedical research. Its contribution can reveal unexplored aspects of their illnesses and allows research priorities to be refined according to theirs. It can also be argued that patients’ experiential knowledge can contribute to biomedical research, by extending it to the most organic aspects of diseases. A few examples of collaboration between medicine and patient associations are promising, even if there is no single, simple methodology to apply. This article provides feedback on a project involving the experiential knowledge of electrohypersensitive persons with a view to developing an experimental protocol to study their condition. It presents the participatory approach with focus groups that was implemented and reflects on ways to take advantage of experiential knowledge. It also demonstrates the complexity of the electrohypersensitivity syndrome and reflects on the difficult transition between the experiential knowledge and the experimental design of provocation studies. KEY MESSAGES Experiential knowledge is a valuable source of information for research and the design of investigation protocols. The participatory approach allows co-designing protocols by drawing on experiential knowledge. The controversial dimension of EHS reveals the complexity of translating experiential knowledge into an experimental protocol.

1 citations

Journal ArticleDOI
TL;DR: Leszczynski et al. as discussed by the authors reviewed the scientific evidence on individual sensitivity to electromagnetic fields (EHS) and published a review of the evidence on EHS in the journal Reviews on Environmental Health.
Abstract: Article Comments on the Review of the scientific evidence on the individual sensitivity to electromagnetic fields (EHS) by Dariusz Leszczynski was published on February 17, 2022 in the journal Reviews on Environmental Health (volume 0, issue 0).

1 citations

References
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Journal ArticleDOI
TL;DR: Using sophisticated brain imaging techniques, the authors show that one’s expectation of the success of a pain treatment can markedly influence its effectiveness, and how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging.
Abstract: Evidence from behavioral and self-reported data suggests that the patients’ beliefs and expectations can shape both therapeutic and adverse effects of any given drug. We investigated how divergent expectancies alter the analgesic efficacy of a potent opioid in healthy volunteers by using brain imaging. The effect of a fixed concentration of the μ-opioid agonist remifentanil on constant heat pain was assessed under three experimental conditions using a within-subject design: with no expectation of analgesia, with expectancy of a positive analgesic effect, and with negative expectancy of analgesia (that is, expectation of hyperalgesia or exacerbation of pain). We used functional magnetic resonance imaging to record brain activity to corroborate the effects of expectations on the analgesic efficacy of the opioid and to elucidate the underlying neural mechanisms. Positive treatment expectancy substantially enhanced (doubled) the analgesic benefit of remifentanil. In contrast, negative treatment expectancy abolished remifentanil analgesia. These subjective effects were substantiated by significant changes in the neural activity in brain regions involved with the coding of pain intensity. The positive expectancy effects were associated with activity in the endogenous pain modulatory system, and the negative expectancy effects with activity in the hippocampus. On the basis of subjective and objective evidence, we contend that an individual’s expectation of a drug’s effect critically influences its therapeutic efficacy and that regulatory brain mechanisms differ as a function of expectancy. We propose that it may be necessary to integrate patients’ beliefs and expectations into drug treatment regimes alongside traditional considerations in order to optimize treatment outcomes.

629 citations

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TL;DR: The hypothesis that mobile phone radiation-induced activation of hsp27 may facilitate the development of brain cancer by inhibiting the cytochrome c/caspase-3 apoptotic pathway and cause an increase in blood-brain barrier permeability through stabilization of endothelial cell stress fibers is put forward.

407 citations

Journal ArticleDOI
TL;DR: Data indicate that different social stimuli, such as words and rituals of the therapeutic act, may change the chemistry and circuitry of the patient's brain, which suggests a cognitive/affective interference with drug action.

331 citations

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TL;DR: The findings question the value of this operation for subacromial shoulder pain and function, and this should be communicated to patients during the shared treatment decision-making process.

310 citations

Journal ArticleDOI
TL;DR: A single locus, identified within a Mendelian framework, can contribute significantly to human pigmentary variation through its role in regulating melanin pigmentation.
Abstract: Humans vary >100-fold in their sensitivity to the harmful effects of ultraviolet radiation. The main determinants of sensitivity are melanin pigmentation and less-well-characterized differences in skin inflammation and repair processes. Pigmentation has a high heritability, but susceptibility to cancers of the skin, a key marker of sun sensitivity, is less heritable. Despite a large number of murine coat-color mutations, only one gene in humans, the melanocortin 1 receptor (MC1R), is known to account for substantial variation in skin and hair color and in skin cancer incidence. MC1R encodes a 317–amino acid G-coupled receptor that controls the relative amounts of the two major melanin classes, eumelanin and pheomelanin. Most persons with red hair are homozygous for alleles of the MC1R gene that show varying degrees of diminished function. More than 65 human MC1R alleles with nonsynonymous changes have been identified, and current evidence suggests that many of them vary in their physiological activity, such that a graded series of responses can be achieved on the basis of (i) dosage effects (of one or two alleles) and (ii) individual differences in the pharmacological profile in response to ligand. Thus, a single locus, identified within a Mendelian framework, can contribute significantly to human pigmentary variation.

284 citations