Journal ArticleDOI
REVIEW ■ : Reorganization of Sensory Systems of Primates after Injury:
Reads0
Chats0
TLDR
The orderly representations of sensory surfaces in the brains of adult mammals have the capacity to reor ganize after injuries that deprive these representations of some of their normal sources of activation.Abstract:
The orderly representations of sensory surfaces in the brains of adult mammals have the capacity to reor ganize after injuries that deprive these representations of some of their normal sources of activation. Such reorganizations can be produced by injury that occurs peripherally, such as nerve damage or amputation, or after injury to the CNS, such as spinal cord damage or cortical lesion. These changes likely are mediated by a number of different mechanisms, and can be extensive and involve the growth of new connections. Finally, some types of reorganizations may help mediate the recovery of lost functions, whereas others may lead to sensory abnormalities and perceptual errors. NEUROSCIENTIST 3:123-130, 1997read more
Citations
More filters
Journal ArticleDOI
Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models.
Deborah C. Rice,Stan Barone +1 more
TL;DR: Of critical concern is the possibility that developmental exposure to neurotoxicants may result in an acceleration of age-related decline in function, and the fact that developmental neurotoxicity that results in small effects can have a profound societal impact when amortized across the entire population and across the life span of humans.
Journal ArticleDOI
Treatment-Induced Cortical Reorganization After Stroke in Humans
TL;DR: This is the first demonstration in humans of a long-term alteration in brain function associated with a therapy-induced improvement in the rehabilitation of movement after neurological injury.
Journal ArticleDOI
Forebrain mechanisms of nociception and pain: analysis through imaging.
TL;DR: An animal model for investigating stimulus-induced rCBF responses in the rat is developed and it is shown that there is a progressive and selective activation of somatosensory and limbic system structures in the brain and brainstem following the subcutaneous injection of formalin.
Journal Article
Extensive reorganization of the somatosensory cortex in adult humans after nervous system injury
Thomas Elbert,Herta Flor,Niels Birbaumer,Stefan Knecht,S. Hampson,Wolfgang Larbig,Edward Taub +6 more
TL;DR: In this article, magnetic source imaging revealed that the topographic representation in the somatosensory cortex of upper extremity amputees was shifted an average of 1.5 cm toward the area that would normally receive input from the now absent nerves supplying the hand and fingers.
Journal ArticleDOI
Peripherally induced oromandibular dystonia
TL;DR: The study indicates that oromandibular-facial trauma, including dental procedures, may precipitate the onset of OMD, especially in predisposed people, and prompt recognition and treatment may prevent further complications.
References
More filters
Journal ArticleDOI
Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation
Herta Flor,Thomas Elbert,Stefan Knecht,Christian Wienbruch,Christo Pantev,Niels Birbaumer,Wolfgang Larbig,Edward Taub +7 more
TL;DR: A very strong direct relationship is reported between the amount of cortical reorganization and the magnitude of phantom limb pain (but not non-painful phantom phenomena) experienced after arm amputation, indicating that phantom-limb pain is related to, and may be a consequence of, plastic changes in primary somatosensory cortex.
Journal ArticleDOI
Somatosensory cortical map changes following digit amputation in adult monkeys
Michael M. Merzenich,R. J. Nelson,Michael P. Stryker,Max S. Cynader,Axel Schoppmann,John M. Zook +5 more
TL;DR: The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits 2 and 3.
Journal ArticleDOI
Massive cortical reorganization after sensory deafferentation in adult macaques
Tim P. Pons,Preston E. Garraghty,Alexander K. Ommaya,Jon H. Kaas,Edward Taub,Mortimer Mishkin +5 more
TL;DR: The results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.
Journal ArticleDOI
Plasticity of sensory and motor maps in adult mammals.
TL;DR: This rev iew addresses questions about the capacity of sensory and motor maps in the brains of adul t mammals to change as a resul t of alterations in the effectiveness of inputs, the availability of effectors, and direct damage.
Journal ArticleDOI
Topographic reorganization of somatosensory cortical areas 3b and 1 in adult monkeys following restricted deafferentation
TL;DR: This paper found that after the median nerve was transected and ligated in adult owl and squirrel monkeys, the cortical sectors representing it within skin surface representations in Areas 3b and 1 were completely occupied by 'new' and expanded representations of surrounding skin fields.