RIP3: a molecular switch for necrosis and inflammation.
Citations
1,373 citations
1,192 citations
Cites background from "RIP3: a molecular switch for necros..."
...Studies using RIP3 knockout mice have provided evidence that this form of cell death is important for response against microbial infections and inflammation-mediated tissue damages (reviewed by Moriwaki and Chan, 2013)....
[...]
1,070 citations
887 citations
808 citations
References
51,099 citations
"RIP3: a molecular switch for necros..." refers background in this paper
...Germline deletion of individual IAP had no overt effects on development (Harlin et al. 2001; Conze et al. 2005; Conte et al. 2006)....
[...]
15,416 citations
"RIP3: a molecular switch for necros..." refers background in this paper
...Deficiency of caspase-8 or FADD in intestinal or skin epithelium spontaneously caused massive inflammation, which was rescued by additional deletion of RIP3 (Kovalenko et al. 2009; Bonnet et al. 2011; Gunther et al. 2011; Welz et al. 2011)....
[...]
9,282 citations
"RIP3: a molecular switch for necros..." refers background in this paper
...Because necrosis also facilitates inflammation, its effect on inflammation in the tumor microenvironment has to be carefully considered (Mantovani et al. 2008)....
[...]
4,490 citations
"RIP3: a molecular switch for necros..." refers background in this paper
...In 1988, TNF was shown to induce necrosis in a cell line derived from the L929 cells that Carswell et al. (1975) used to examine TNF activity (Laster et al. 1988)....
[...]
...Carswell et al. (1975) originally discovered TNF as the factor that induces rapid hemorrhagic necrosis in cancer cells....
[...]
3,942 citations
"RIP3: a molecular switch for necros..." refers background in this paper
...However, mice deficient in the essential apoptosis regulators Bax and Bak developed normally (Wei et al. 2001), indicating that nonapoptotic cell death can contribute to embryonic development when apoptosis is impaired....
[...]