Risk factors associated with household transmission of SARS-CoV-2 in Negeri Sembilan, Malaysia.
David Chun-Ern Ng,Kah Kee Tan,Ling Chin,Xiang Lin Cheng,Thalitha Vijayakulasingam,Damian Wen Xian Liew,Nor Zanariah Zainol Abidin,Ming Lee Lee,Kurubaran Ganasegeran,Erwin Jiayuan Khoo +9 more
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TLDR
In this paper, the authors conducted a study to characterise the transmission dynamics and identify risk factors for household transmission of SARS-CoV-2 in Negeri Sembilan, Malaysia.Abstract:
Aim Households are a significant venue for the transmission of SARS-CoV-2. We conducted a study to characterise the transmission dynamics and identify risk factors for household transmission of SARS-CoV-2 in Negeri Sembilan, Malaysia. Methods This retrospective observational study included 185 families of paediatric COVID-19 cases from 1 February 2020 to 31 December 2020. We identified the index case for each household and gathered the socio-demographic, epidemiological investigation results and risk factors for household transmission from medical case records. The secondary attack rate was calculated, and logistic regression analyses were used to identify risk factors associated with secondary household transmission of SARS-CoV-2. Results Of the 848 household contacts, 466 acquired secondary infections, resulting in a secondary attack rate of 55%. The median age of the secondary cases was 12 years. Female household contacts and household contacts who slept in the same room with the index case were significantly associated with increased risk for COVID-19. Other independent risk factors associated with higher transmission risk in the household included an index case who was symptomatic, a household index case aged greater than 18 years and a male household index case. Conclusions High rates of household transmission of COVID-19 were found, indicating households were a major setting of transmission of SARS-CoV-2. Our data provide insight into the risk factors for household transmission of SARS-CoV-2 in Malaysia.read more
Citations
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Household Secondary Attack Rates of SARS-CoV-2 by Variant and Vaccination Status
TL;DR: The results suggest that emerging SARS-CoV-2 variants of concern have increased transmissibility and the changes in estimated vaccine effectiveness underscore the challenges of developing effective vaccines concomitant with viral evolution.
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Household secondary attack rates of SARS-CoV-2 by variant and vaccination status: an updated systematic review and meta-analysis
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The role of children in household transmission of COVID-19: a systematic review and meta-analysis
TL;DR: In this paper , the authors explored the household transmissibility of SARS-CoV-2 in children in new-variants dominating periods and found that younger children were as susceptible as older children (RR = 0.18-0.30).
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Impact of Age and Symptom Development on SARS-CoV-2 Transmission in Households With Children—Maryland, New York, and Utah, August 2020–October 2021
Kelsey M. Sumner,Ruth A. Karron,Melissa S. Stockwell,Fatimah S. Dawood,Joseph B. Stanford,Alexandra M. Mellis,Emily Hacker,P. Thind,Maria Julia E Castro,John Paul Harris,Maria Deloria Knoll,Elizabeth Schappell,M. Hetrich,Jazmin Duque,Zuha Jeddy,Kim Altunkaynak,Brandon Poe,Jennifer K. Meece,Elisha Stefanski,Suxiang Tong,Justin S. Lee,Ashton Dixon,Vic Veguilla,Melissa A. Rolfes,Christina A. Porucznik +24 more
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Comparison of Severe Viral Pneumonia Caused by SARS-CoV-2 and Other Respiratory Viruses Among Malaysian Children During the COVID-19 Pandemic
David Chun-Ern Ng,Kah Kee Tan,Grace Sieng Sing Ting,Chin Kai Ling,Nur Fadzreena Binti Fadzilah,Shir Fong Tan,Thayasheri Subramaniam,N. E. Zailanalhuddin,Hui-Yi Lim,Suhaila Baharuddin,Yee-Lean Lee,Airena Mohamad Nor,Erwin Jiayuan Khoo +12 more
TL;DR: The etiology of severe pneumonia in children evolved with the epidemic curve of COVID-19 and school closures and children with severe pneumonia due to SARS-CoV-2 experienced a milder clinical course when compared to other respiratory viruses.
References
More filters
Journal ArticleDOI
Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.
Qifang Bi,Yongsheng Wu,Shujiang Mei,Chenfei Ye,Xuan Zou,Zhen Zhang,Xiaojian Liu,Lan Wei,Shaun A. Truelove,Tong Zhang,Wei Gao,Cong Cheng,Xiujuan Tang,Xiaoliang Wu,Yu Wu,Binbin Sun,Suli Huang,Yu Sun,Juncen Zhang,Ting Ma,Justin Lessler,Tiejian Feng +21 more
TL;DR: An analysis of data from the Shenzhen Center for Disease Control and Prevention identified 391 SARS-CoV-2 cases and 1286 close contacts shows that isolation and contact tracing reduce the time during which cases are infectious in the community, thereby reducing the R.
Journal ArticleDOI
Contact Tracing Assessment of COVID-19 Transmission Dynamics in Taiwan and Risk at Different Exposure Periods Before and After Symptom Onset.
TL;DR: High transmissibility of COVID-19 before and immediately after symptom onset suggests that finding and isolating symptomatic patients alone may not suffice to interrupt transmission, and that more generalized measures might be required, such as social distancing.
Journal ArticleDOI
Household Transmission of SARS-CoV-2: A Systematic Review and Meta-analysis.
Zachary J. Madewell,Yang Yang,Ira M. Longini,M. Elizabeth Halloran,M. Elizabeth Halloran,Natalie E. Dean +5 more
TL;DR: The findings suggest that households are and will continue to be important venues for transmission, even in areas where community transmission is reduced.
Journal ArticleDOI
Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study.
Qin Long Jing,Ming Jin Liu,Zhou Bin Zhang,Li Qun Fang,Jun Yuan,An Ran Zhang,Natalie E. Dean,Lei Luo,Meng Meng Ma,Ira M. Longini,Eben Kenah,Ying Lu,Yu Ma,Neda Jalali,Zhicong Yang,Yang Yang +15 more
TL;DR: SARS-CoV-2 is more transmissible in households than SARS- coV and Middle East respiratory syndrome coronavirus and older individuals (aged ≥60 years) are the most susceptible to household transmission of Sars-Cov-2.
Journal ArticleDOI
Transmission of SARS-COV-2 infections in households - Tennessee and Wisconsin, April-September 2020
Carlos G. Grijalva,Melissa A Rolfes,Yuwei Zhu,Huong Q. McLean,Kayla E. Hanson,Edward A. Belongia,Natasha B. Halasa,Ahra Kim,Carrie Reed,Alicia M. Fry,H. Keipp Talbot +10 more
TL;DR: Because household transmission of SARS-CoV-2 is common and can occur rapidly after the index patient's illness onset, persons should self-isolate immediately at the onset of COVID-like symptoms, at the time of testing as a result of a high risk exposure, or at the times of a positive test result.