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Journal ArticleDOI

Risk genes in head and neck cancer: A systematic review and meta-analysis of last 5 years

01 Mar 2014-Oral Oncology (Pergamon)-Vol. 50, Iss: 3, pp 178-188
TL;DR: The aim of this work was to identify risk genes related to the development and progression of squamous cell carcinoma head and neck (SCCHN) and do a meta-analysis of available estimates, showing no significant association between different allelic variants of Arg72Pro rs1042522 and SCCHN risk.
About: This article is published in Oral Oncology.The article was published on 2014-03-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Odds ratio.

Summary (1 min read)

Jump to: [INTRODUCTION][METHODS][RESULTS][DISCUSSION] and [Contributors]

INTRODUCTION

  • Head and Neck Carcinoma (HNC), of which the majority are squamous cell carcinomas of the head and neck , is the sixth most prevalent cancers in mankind and, presents high morbidity and low rates of survival.
  • It is known that the apoptotic and proliferation genes are involved in cancer development and these could be useful as a biomarker of this pathology.
  • Systematic reviews and meta-analysis allow stronger and more generalized conclusions for identifying some models of risk markers.
  • This has led to the production of an enormous number of epidemiologic papers about the relationship between genetic polymorphism and disease.
  • Focused on the microenvironment (focal proliferative lesions precede cancer) or morphostasis theory (morphostatic fields maintain the normal behavior of the cell and its tissue micro-architecture), also known as There are two subtypes.

METHODS

  • This study was made according to the PRISMA reporting items for systematic reviews and metaanalysis guidelines.
  • The search strategy included the following keywords (variably combined): “oral cancer”, “oral cancer polymorphism”, “oncogene”, “tumor suppressor gene”, “squamous cell carcinoma”, “head and neck cancer”.
  • Abstracts and titles of all the identified papers obtained by the electronic search were evaluated.
  • All studies which met the inclusion criteria (presence/absence of mutation and/or polymorphism by PCR, Odd Ratios (OR) adjusted for alcohol and tobacco, 95% Confidence Intervals (CIs) were assessed in order to establish their validity and subsequent data extraction.

RESULTS

  • Nineteen original reports were retrieved from 2285 potential reports that addressed the issue of DNA gene / polymorphisms and risk of SCCHN.
  • Twelve of the studies were of unpaired casecontrol design, 6 studies were matched case-control, and 1 nested case-control (Table 1).
  • TP53, GSTM1, and CYPA1were described in four, three, and two studies respectively, which were considered for meta-analysis.
  • No study reported a significant association between this polymorphism and SCCHN risk.

DISCUSSION

  • There are still numerous points that are unclear or unknown.
  • 57 The ADH7A92G 23 polymorphism has been described as associated with diminished SCCHN risk.
  • As well as smoking, alcohol consumption is another known cancer risk factor.
  • This gene is related to an increase of tumor survival because it promotes angiogenesis and inhibits apoptosis.
  • The model proposed in this work shows the genetic composition of individuals that could be at risk or protected against malignancy transformation.

Contributors

  • MB conceived and coordinated the project, made all the analyses, and wrote the report.
  • All authors contributed individual patient data from trials and commented on the initial surrogate-end point protocol and on drafts of the report.

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Citations
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Journal ArticleDOI
TL;DR: The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.
Abstract: The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas (HNSCC). Genome-wide sequencing projects have identified a number of recurrently mutated genes, including unexpected alterations in the NOTCH pathway and chromatin related genes. Gene-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma biology. The identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic strategies. The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes.

80 citations

Journal ArticleDOI
TL;DR: This meta-analysis found frequency of toothbrushing was significantly associated with HNC risk and it is suggested that the frequency be twice per day (morning and night).

56 citations


Cites background from "Risk genes in head and neck cancer:..."

  • ...Other risk factors including genetic factors [3,4], human papillomavirus (HPV) infections [5], periodontal disease [6], tooth loss [7], poor oral hygiene [8], and poor dental status [9] have also been identified in the development of HNC....

    [...]

Journal ArticleDOI
TL;DR: It is demonstrated that localized delivery of FR-targeted PAMAM dendrimer G4 complexed with siVEGFA resulted in pronounced tumor suppression in an HN12 xenograft tumor model.

47 citations

Journal ArticleDOI
TL;DR: The results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoInitiators.
Abstract: Free-radical photopolymerization initiated by photoinitiators is an important method to make tissue engineering scaffolds. To advance understanding of photoinitiator cytocompatibility, we examined three photoinitiators including 2,2-dimethoxy-2-phenylacetophenone (DMPA), Irgacure 2959 (I-2959), and eosin Y photoinitiating system (EY) in terms of their effects on the viability of HN4 cells and expression levels of intracellular AKT and its phosphorylated form p-AKT. Our results show that the photoinitiators and their UV-exposed counterparts affect intracellular AKT signaling, which can be used in conjunction with cell viability for cytocompatibility assessment of photoinitiators.

45 citations

Journal ArticleDOI
01 Nov 2015-Medicine
TL;DR: It is suggested that gene-environment interactions between the TIMP3 rs9862 polymorphisms and betel quid may alter oral cancer susceptibility and tumor growth in Taiwanese men.

31 citations


Cites background from "Risk genes in head and neck cancer:..."

  • ...Previous studies have reported that SNPs located within a promoter or other regulatory regions of genes are associated with the development of certain diseases,(4) and several SNPs have been reported as predictive factors for a high OSCC risk.(5) Tissue inhibitor of metalloproteinase-3 (TIMP3) is a member of the TIMP family; it is a 24 kDa secretory protein, and unlike its other family members, it binds firmly to the extracellular matrix....

    [...]

References
More filters
01 Jan 2006
TL;DR: The histopathological, biochemical, immunocytochemical and genetic alterations observed during the course of experimental carcinogenesis in the submandibular gland of the rat could constitute reproducible indices of malignant transformation applicable to human oncogenesis, given the high degree of homology between the oncogenes of mice, rats and human beings.
Abstract: The present study evaluates the phenotypic and genotypic changes that take place during early oncogenesis. The submandibular glands of male rats were injected with a 0.5% solution of 9,10-dimethyl-1,2-benzanthracene (DMBA) in acetone. Gland samples were taken at 0, 7, 30 and 150 days post-injection and submitted to histological, biochemical, immunocytochemical and PCR evaluation. Histopathological analysis was performed on hematoxylin-eosin stained slides. Total protein content was assessed by Lowry's method and the protein profile was analyzed by 12% SDS-PAGE. Bcl-2 was demonstrated by silver-enhanced gold immunolabeling. p53 immunolabeling was performed using the streptavidin-biotin system. All the treated animals developed carcinoma-like lesions at 30 and 150 days. Total protein concentration rose significantly (p asn) in the protein molecule. Our results suggest that the early histopathological changes correspond to quantitative and qualitative protein changes. The histopathological, biochemical, immunocytochemical and genetic alterations observed during the course of experimental carcinogenesis in the submandibular gland of the rat could constitute reproducible indices of malignant transformation applicable to human oncogenesis, given the high degree of homology between the oncogenes of mice, rats and human beings.

4 citations

Journal Article
TL;DR: L-MYC polymorphism was not a significant marker for predicting susceptibility to OSCC in this population but may be a useful marker for identifying patient susceptibility to tumor recurrence and to developing OSCC, especially in individuals having a family history of cancer.
Abstract: Background: An association between restriction fragment length polymorphism (RFLP) of known oncogenes and a predisposition to develop cancer has been postulated. Our aim was to test the hypothesis that there was an association between the L-MYC S allele in oral squamous cell carcinoma (OSCC) and a predisposition for the disease. Patients and Methods: The distribution of L-MYC polymorphism in 80 patients with OSCC was determined by polymerase chain reaction-based RFLP and compared with that of 60 healthy controls. Results: There was no significant difference between patients with OSCC and healthy controls. Patients with the L-MYC S allele and a positive family history of cancer were found to be 1.74 times more at risk for OSCC than those with any other genotype (95% confidence interval=0.88-3.45). Moreover, tumor recurrence was higher among individuals carrying a L-MYC S allele than those with any other allele type. Conclusion: L-MYC polymorphism was not a significant marker for predicting susceptibility to OSCC in this population but may be a useful marker for identifying patient susceptibility to tumor recurrence and to developing OSCC, especially in individuals having a family history of cancer.

4 citations


Additional excerpts

  • ...[63] Turkish CC matched....

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01 Mar 2012
TL;DR: The aim of this paper is to describe the characteristic of complex chronic diseases and some of the current methods of study of these in the health area and to suggest a best methodological strategy for complex diseases.
Abstract: UNLABELLED The Non Communicable Complex Disease (NCCD) are the leading causes of death in the world, causing more deaths each year than all other combined causes. The approximately 80% of deaths were caused by NCCD and occured in low and middle income countries. However, NCCD deaths could be avoided by prevention programs and early diagnosis. The challenge of the multifactorial phenotypes is to achieve a valid strategy for identifying risk individuals at the population. These strategies may be addressed to screening population or generating causal predictive models for early detection, interpreting the root causes that create the condition. The aim of this paper is to describe the characteristic of complex chronic diseases and some of the current methods of study of these in the health area . CONCLUSIONS Interdisciplinary work, a team of health professionals belonging to different areas allows for an adequate management of complex diseases. The application of graph models, such as DAG's, is a valuable tool for a better adjustment of the statistical model, which allows an appropriate correspondence with the actual health model of these illnesses. And the best methodological strategy for complex diseases is the early diagnosis and the monitoring of risk groups and therapy monitoring of patients diagnosed.

3 citations


"Risk genes in head and neck cancer:..." refers background or methods in this paper

  • ...The evaluation of diagnostic markers such as symptoms and genetic tests helps to increase the sensitivity or specificity of the determination of the presence/ absence of malignancy [2,3,29]....

    [...]

  • ...These models may help in screening, early diagnosis and/or therapy in the clinic [2–5]....

    [...]

Related Papers (5)
Frequently Asked Questions (14)
Q1. What are the contributions mentioned in the paper "Risk genes in head and neck cancer: a systematic review and meta-analysis of last 5 years" ?

The case-control studies guidelines of the Scottish Intercollegiate Guidelines Network and MOOSE are followed. Two members of the team ( AB, AMZ ) evaluated complete articles independently and double-blinded, to establish their quality. The papers were encoded and delivered independently to each reviewer. 

It is known that the p53 suppressor tumor gene has a key role in stress cellular response, to preserve genome stability, and it is universally recognized as a human cancer marker when it is mutated. 

Overexpression of the DEC1 Protein InducesSenescence In Vitro and Is Related to Better Survival in Esophageal Squamous Cell Carcinoma. 

59 The AA genotype of the ADH1B R48H gene encodes an enzyme that is about 40 times more active than the enzyme encoded by AG and GG genotypes. 

The evaluation of diagnostic markers such as symptoms and genetic tests helps to increase the sensitivity or specificity of the determination of the presence/absence of malignancy. 

Authors such as Piva et al. 48 have observed inflammatory infiltrate in epithelial dysplasia with overexpression of NFKB and TNF-α, establishing a connection between the cancer and inflammation. 

61,62 Research by Su et al. 62 showed that allele G of CRYAB C-802G is correlated to breast cancer risk, and could be useful as a clinical marker for its early detection. 

the model proposed in this paper could fit models 1, 2, and 3 because it considers such epigenetic events as inflammation, mutational compounds such as tobacco and alcohol, and genomic stability and the cell cycle regulation process. 

The authors conducted a systematic review and meta-analysis of case-control studies from the MEDLINE, Scopus, Cochrane, and CancerLit databases between January 2007 and January 2013. 

3,29 Cancer is a complex pathology, and its incidence and survival index are closely related to social, cultural and socio-economic determinants of health. 

Pradhan S, Nagashri MN, Gopinath KS, Kumar A.Expression profiling of CYP1B1 in oral squamous cell carcinoma: counter intuitive down regulation in tumors. 

This gene encodes glutathioneStransferase Mu 1, which is critical to detoxification and the removal of electrophilic carcinogens. 

The identification of a predictive model of risk polymorphisms could help in early diagnosis, and in understanding disease recurrence and/or progression in the subset of patients. 

A search was made of combined electronic databases, and the bibliographies of all selected papers were searched to identify grey literature.