Rituximab for induction and maintenance treatment of ANCA-associated vasculitides: a multicentre retrospective study on 80 patients
Pierre Charles,Antoine Néel,Nathalie Tieulie,Arnaud Hot,Grégory Pugnet,Olivier Decaux,Isabelle Marie,Mehdi Khellaf,Jean-Emmanuel Kahn,Alexandre Karras,Jean-Marc Ziza,Christophe Deligny,Colas Tcherakian,Loïc Guillevin +13 more
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TLDR
Rituximab was able to induce AAV remission and seemed to maintain remission better than other agents, but caution is needed concerning its safety, especially regarding bacterial infections, in this population of patients.Abstract:
Objectives. Rituximab has been shown to induce remission of ANCA-associated vasculitides (AAVs). Our study was undertaken to describe AAV clinical responses to rituximab used for remission-induction and/or maintenance therapy, assess rituximab’s safety profile and evaluate French clinical practices. Methods. This retrospective study concerned AAV patients who had received one or more rituximab infusion between 2002 and January 2011 and had follow-up lasting 512 months. Results. Eighty patients were included, most with refractory or relapsing AAV: 70 (88%) with granulomatosis with polyangiitis (GPA), 9 (11%) with microscopic polyangiitis and 1 (1%) with eosinophilic GPA. Rituximab was the first agent used to induce remission in 73 patients. The two most commonly administered regimens were an infusion of 375 mg/m 2 /week for 4 weeks (54 patients) and an infusion of 1 g every 2 weeks for a month (16 patients). Rituximab was first prescribed to maintain remission in seven patients. Respective 1-, 2-, and 3-year relapse-free survival rates after the first infusion were 80% (95% CI 72, 89), 63% (51, 77) and 52% (39, 70). Relapse-free survival was longer for patients receiving rituximab maintenance therapy (P = 0.002). Among 22 (28%) rituximab-treated patients experiencing severe adverse events, 12 (15%) had infectious complications leading to 4 (5%) deaths. Only 15 (19%) patients had received anti-pneumococcal vaccine before rituximab. Conclusion. Rituximab was able to induce AAV remission and seemed to maintain remission better than other agents, but caution is needed concerning its safety, especially regarding bacterial infections, in this population.read more
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Guidelines on the use of therapeutic apheresis in clinical practice - Evidence-based approach from the writing committee of the american society for apheresis
Joseph E. Schwartz,Jeffrey L. Winters,Anand Padmanabhan,Rasheed A. Balogun,Meghan Delaney,Michael L. Linenberger,Zbigniew M. Szczepiorkowski,Mark E. Williams,Yanyun Wu,Beth H. Shaz +9 more
TL;DR: This Sixth Edition of the ASFA Special Issue has further improved the process of using evidence‐based medicine in the recommendations by consistently applying the category and GRADE system definitions, but eliminating the “level of evidence” criteria.
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Introduction to Special Issue: Clinical Applications of Therapeutic Apheresis: An Evidence Based Approach. 7th Edition
Joseph E. Schwartz,Anand Padmanabhan,Nicole A. Aqui,Rasheed A. Balogun,Laura Connelly-Smith,Meghan Delaney,Nancy M. Dunbar,Volker Witt,Yanyun Wu,Beth H. Shaz,Beth H. Shaz,Beth H. Shaz +11 more
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Comparison of individually tailored versus fixed-schedule rituximab regimen to maintain ANCA-associated vasculitis remission: results of a multicentre, randomised controlled, phase III trial (MAINRITSAN2).
Pierre Charles,Benjamin Terrier,Elodie Perrodeau,Pascal Cohen,Stanislas Faguer,Antoine Huart,Mohamed Hamidou,Christian Agard,Bernard Bonnotte,Maxime Samson,Alexandre Karras,Noémie Jourde-Chiche,François Lifermann,P. Gobert,Catherine Hanrotel-Saliou,Pascal Godmer,Nicolas Martin-Silva,Grégory Pugnet,Marie Matignon,Olivier Aumaître,Jean-François Viallard,François Maurier,Nadine Meaux-Ruault,Sophie Rivière,Jean Sibilia,Xavier Puéchal,Philippe Ravaud,Luc Mouthon,Loïc Guillevin +28 more
TL;DR: AAV relapse rates did not differ significantly between individually tailored and fixed-schedule rituximab regimens, and individually tailored-arm patients received fewer ritUXimab infusions.
Journal ArticleDOI
Updates in ANCA-associated vasculitis.
TL;DR: The induction treatment for severe granulomatosis with polyangiitis and microscopic polyang iitis is relatively well codified but does not (yet) really differ by precise diagnosis or ANCA type, and the optimal maintenance strategy following rituximab-based induction therapy remains to be determined.
Journal ArticleDOI
Long-Term Rituximab Use to Maintain Remission of Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Randomized Trial.
Pierre Charles,Elodie Perrodeau,Maxime Samson,Bernard Bonnotte,Antoine Néel,Christian Agard,Antoine Huart,Alexandre Karras,François Lifermann,Pascal Godmer,Pascal Cohen,Catherine Hanrotel-Saliou,Nicolas Martin-Silva,Grégory Pugnet,François Maurier,Jean Sibilia,Pierre-Louis Carron,P. Gobert,Nadine Meaux-Ruault,Thomas Le Gallou,Stéphane Vinzio,Jean-François Viallard,Eric Hachulla,Christine Vinter,Xavier Puéchal,Benjamin Terrier,Philippe Ravaud,Luc Mouthon,Loïc Guillevin +28 more
TL;DR: Extended therapy with biannual rituximab infusions over 18 months was associated with a lower incidence of AAV relapse compared with standard maintenance therapy.
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Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
John H. Stone,Peter A. Merkel,Robert Spiera,Philip Seo,Carol A. Langford,Gary S. Hoffman,Cees G. M. Kallenberg,E. William St. Clair,Anthony M. Turkiewicz,Nadia K. Tchao,Lisa Webber,Linna Ding,Lourdes P. Sejismundo,Kathleen Mieras,David Weitzenkamp,David Ikle,Vicki Seyfert-Margolis,Mark Mueller,Paul Brunetta,Nancy B. Allen,Fernando C. Fervenza,Duvuru Geetha,Karina A. Keogh,Eugene Y. Kissin,Paul A. Monach,Tobias Peikert,Coen A. Stegeman,Steven R. Ytterberg,Ulrich Specks +28 more
TL;DR: Rituximab therapy was not inferior to daily cyclophosphamide treatment for induction of remission in severe ANCA-associated vasculitis and may be superior in relapsing disease.
Journal ArticleDOI
Rituximab versus Cyclophosphamide in ANCA-Associated Renal Vasculitis
Rachel B Jones,Jan Willem Cohen Tervaert,Thomas H. Hauser,Raashid Luqmani,Matthew D. Morgan,Chen Au Peh,Caroline O. S. Savage,Mårten Segelmark,Vladimir Tesar,Pieter van Paassen,D Walsh,Michael Walsh,Kerstin Westman,David Jayne +13 more
TL;DR: A rituximab-based regimen was not superior to standard intravenous cyclophosphamide for severe ANCA-associated vasculitis and was not associated with reductions in early severe adverse events.
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TL;DR: A clinical index of disease activity is devised, its use in several forms of necrotizing vasculitis is evaluated, and the weighted score is based on symptoms and signs in nine separate organ systems.
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