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RNA-Binding Proteins in Cancer: Old Players and New Actors
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TLDR
Evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer are reviewed.Abstract:
RNA-binding proteins (RBPs) are key players in post-transcriptional events. The combination of versatility of their RNA-binding domains with structural flexibility enables RBPs to control the metabolism of a large array of transcripts. Perturbations in RBP–RNA networks activity have been causally associated with cancer development, but the rational framework describing these contributions remains fragmented. We review here the evidence that RBPs modulate multiple cancer traits, emphasize their functional diversity, and assess future trends in the study of RBPs in cancer.read more
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Influenza A Virus Cell Entry, Replication, Virion Assembly and Movement.
TL;DR: The aim of this review is to present the current mechanistic understanding for how IAVs facilitate cell entry, replication, virion assembly, and intercellular movement, in an effort to highlight some of the unanswered questions regarding the coordination of the IAV infection process.
Journal ArticleDOI
Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals.
Peifeng Ji,Wanying Wu,Shuai Chen,Yi Zheng,Lin Zhou,Jinyang Zhang,Hao Cheng,Jin Yan,Shaogeng Zhang,Penghui Yang,Fangqing Zhao +10 more
TL;DR: A large-scale study of circRNA repertoires from multiple tissues from human, macaque, and mouse finds thousands of evolutionarily conserved circRNAs that were valuable for functional screening and prioritization and constructed both species-specific and conserved gene co-expression networks.
Journal ArticleDOI
Identification of cancer driver genes based on nucleotide context
Felix Dietlein,Felix Dietlein,Donate Weghorn,Donate Weghorn,Amaro Taylor-Weiner,Amaro Taylor-Weiner,André Richters,Brendan Reardon,Brendan Reardon,David Liu,David Liu,Eric S. Lander,Eliezer M. Van Allen,Eliezer M. Van Allen,Shamil R. Sunyaev,Shamil R. Sunyaev +15 more
TL;DR: This study observed that mutations in contexts that deviate from the characteristic contexts around passenger mutations provide a signal in favor of driver genes, and developed a method that combines this feature with the signals traditionally used for driver-gene identification.
Journal ArticleDOI
POSTAR2: deciphering the post-transcriptional regulatory logics.
Yumin Zhu,Gang Xu,Yucheng T. Yang,Zhiyu Xu,Xinduo Chen,Binbin Shi,Daoxin Xie,Zhi John Lu,Pengyuan Wang +8 more
TL;DR: The current database version of POSTAR2 will help researchers investigate the post-transcriptional regulatory logics coordinated by RNA-binding proteins and translational landscape of cellular RNAs.
Journal ArticleDOI
RNA-binding proteins in tumor progression
TL;DR: This analysis is an important step towards the comprehensive characterization of post-transcriptional gene regulation involved in tumor progression.
References
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
Supporting Online Material for Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron M. Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: Yu et al. as discussed by the authors proposed online material for induced pluripotent stem cell lines derived from human Somatic Cells, which can be used for transplanting human stem cells to humans.
Journal ArticleDOI
Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
Markus Hafner,Markus Landthaler,Lukas Burger,Mohsen Khorshid,Jean Hausser,Philipp Berninger,Andrea Rothballer,Manuel Ascano,Anna-Carina Jungkamp,Mathias Munschauer,Alexander Ulrich,Greg S. Wardle,Scott Dewell,Mihaela Zavolan,Thomas Tuschl +14 more
TL;DR: This study developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs and revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions.