RNA-guided editing of bacterial genomes using CRISPR-Cas systems
Citations
8,663 citations
4,361 citations
4,282 citations
Cites background from "RNA-guided editing of bacterial gen..."
...While our paper was under review, several very recent studies reported the use of wild-type Cas9/CRISPR for targeted genome editing in diverse organisms (Mali et al., 2013; Cong et al., 2013; Jinek et al., 2013; Jiang et al., 2013; Hwang et al., 2013; Cho et al., 2013)....
[...]
...Thus, we expected that cotransformation of wild-type Cas9 and an sgRNA that targets the E. coli genome would direct double-stranded breaks at the target site (Mali et al., 2013; Jiang et al., 2013)....
[...]
...Very recently, it has been demonstrated that the Cas9/CRISPR can be harnessed for site-selective RNA-guided genome editing (Figure 1A) (Mali et al., 2013; Cong et al., 2013; Jinek et al., 2013; Jiang et al., 2013; Hwang et al., 2013; Cho et al., 2013)....
[...]
4,113 citations
3,436 citations
References
12,865 citations
12,265 citations
10,746 citations
8,197 citations
8,117 citations