RNA interference in the nucleus: roles for small RNAs in transcription, epigenetics and beyond
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TLDR
A growing number of functions are emerging for RNA interference in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm, and increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery.Abstract:
A growing number of functions are emerging for RNA interference (RNAi) in the nucleus, in addition to well-characterized roles in post-transcriptional gene silencing in the cytoplasm. Epigenetic modifications directed by small RNAs have been shown to cause transcriptional repression in plants, fungi and animals. Additionally, increasing evidence indicates that RNAi regulates transcription through interaction with transcriptional machinery. Nuclear small RNAs include small interfering RNAs (siRNAs) and PIWI-interacting RNAs (piRNAs) and are implicated in nuclear processes such as transposon regulation, heterochromatin formation, developmental gene regulation and genome stability.read more
Citations
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References
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Journal ArticleDOI
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Julius Brennecke,Alexei A. Aravin,Alexander Stark,Monica Dus,Manolis Kellis,Ravi Sachidanandam,Gregory J. Hannon +6 more
TL;DR: Examination of piwi-interacting RNAs associated with each Drosophila Piwi protein finds that Piwi and Aubergine bind RNAs that are predominantly antisense to transposons, whereas Ago3 complexes contain predominantly sense piRNAs.
Journal ArticleDOI
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Tom Volpe,Catherine A. Kidner,Ira M. Hall,Ira M. Hall,Grace Teng,Grace Teng,Shiv I. S. Grewal,Robert A. Martienssen +7 more
TL;DR: It is proposed that double-stranded RNA arising from centromeric repeats targets formation and maintenance of heterochromatin through RNAi.
Journal ArticleDOI
A novel class of small RNAs bind to MILI protein in mouse testes
Alexei A. Aravin,Dimos Gaidatzis,Sébastien Pfeffer,Sébastien Pfeffer,Sébastien Pfeffer,Mariana Lagos-Quintana,Pablo Landgraf,Nicola Iovino,Patricia L. Morris,Michael J. Brownstein,Satomi Kuramochi-Miyagawa,Toru Nakano,Minchen Chien,James J. Russo,Jingyue Ju,Robert L. Sheridan,Chris Sander,Mihaela Zavolan,Thomas Tuschl +18 more
TL;DR: A new class of small RNAs that bind to MILI in mouse male germ cells, where they accumulate at the onset of meiosis are described, and are referred to as ‘Piwi-interacting RNAs’ or piRNAs.
Journal ArticleDOI
RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
André Verdel,Songtao Jia,Scott A. Gerber,Tomoyasu Sugiyama,Steven P. Gygi,Shiv I. S. Grewal,Danesh Moazed +6 more
TL;DR: The purification of an RNAi effector complex termed RITS (RNA-induced initiation of transcriptional gene silencing) that is required for heterochromatin assembly in fission yeast is described and a mechanism for the role of the RNAi machinery and small RNAs in targeting of heterochROMatin complexes and epigenetic genesilencing at specific chromosomal loci is suggested.
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