RNA-Seq: a revolutionary tool for transcriptomics
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Cites background from "RNA-Seq: a revolutionary tool for t..."
...Wang Z, Gerstein M, Snyder M: RNA-Seq: a revolutionary tool for transcriptomics....
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...Sequence alignment is one of the first steps for downstream data analyses, during which sequencing reads have to be mapped either to other reads to form a genome (also known as de novo sequence assembly) [1,4]; or on to a reference DNA sequence, usually a genome, for downstream applications such as single-nucleotide polymorphism (SNP) discovery [3], Chip-Seq [5] or RNA-Seq [6]....
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151 citations
150 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...By contrast, RNA-seq could, in principle, detect any expressed RNAs and identify the ‘aberrant’ junction sequence, thereby signaling the presence of circRNAs [29]....
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149 citations
Cites background or methods from "RNA-Seq: a revolutionary tool for t..."
...The key aims of transcriptomics are to catalogue all species of transcripts, denote the transcriptional structure of gene, and quantify the expression level of each transcript during development and under different conditions [75]....
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...Up to now, various methods have been developed to study transcriptome, including hybridization-or sequence-based approaches [75]....
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149 citations
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"RNA-Seq: a revolutionary tool for t..." refers methods in this paper
...There are several programs for mapping reads to the genome, including ELAND, SOA...
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