RNA-Seq: a revolutionary tool for transcriptomics
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144 citations
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...We note that microarray data are also less suitable than RNA-seq for the purpose of detecting v-eQTL, because saturation of signal limits discrimination at extremes (Wang et al., 2009)....
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144 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...…at multiple stages of development, can be used to quantify the abundances of all transcripts in an organism’s genome, even for non-model species (Wang et al., 2009), providing a foundation for defining modules of co-expressed genes and examining the regulatory relationships among these modules…...
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144 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...To obtain the analytical data for the diverse molecular constituents, ‘-omic’ platforms, including transcriptomics [2], metabolomics [3, 4], lipidomics [5, 6] and proteomics [7, 8] have emerged to provide the ever growing tool-box for successful systems biology investigations [9]....
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144 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...accurately measure changes in gene expression [46]....
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...of transcripts, which are not well suited to measure overall mRNA expression [46]....
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144 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...Future cancer and other disease profiling studies will benefit from the use of high-throughput RNA sequencing, since this technology can yield data sets with greater coverage of the transcriptome as well as greater quantitative accuracy (4, 55)....
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References
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"RNA-Seq: a revolutionary tool for t..." refers methods in this paper
...There are several programs for mapping reads to the genome, including ELAND, SOA...
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