RNA-Seq: a revolutionary tool for transcriptomics
Citations
122 citations
Cites background or methods from "RNA-Seq: a revolutionary tool for t..."
...modifications [3]....
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...[3, 6]....
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...The later method provides good coverage of 30 sequences but biases against the body of the transcript [3]....
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...These newly developed ‘ultrahigh-throughput’ sequencing technologies promise to provide a much more detailed view of plant transcriptomes and to revolutionize the way eukaryotic transcriptomes are analyzed [3]....
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...However, this approach is deemed less useful when reads are generated from repetitive regions with high copy numbers [3]....
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122 citations
Cites methods from "RNA-Seq: a revolutionary tool for t..."
...Next-generation high-throughput RNA sequencing technology (RNA-Seq) is a recently-developed method for discovering, profiling, and quantifying RNA transcripts with several advantages over other expression profiling technologies including higher sensitivity and the ability to detect splicing isoforms and somatic mutations [16]....
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121 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...Over the past decade, numerous noncoding RNAs (ncRNAs) have been identified in human (1), mouse (2) and other organisms (3–5) due to the advances in high-throughput sequencing (6)....
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121 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...It has excelled at determining exon boundaries and as a corollary, at detecting and quantifying alternative splicing [9,13,15-17]....
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121 citations
Cites background from "RNA-Seq: a revolutionary tool for t..."
...Transcriptome sequencing (RNA-seq) is a powerful and emerging technology that allows researchers to measure differential expression of genes more accurately than when using microarrays (21)....
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References
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"RNA-Seq: a revolutionary tool for t..." refers methods in this paper
...There are several programs for mapping reads to the genome, including ELAND, SOA...
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