Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Citations
10,685 citations
Cites background from "Role of adaptor TRIF in the MyD88-i..."
...TRAM, another TIR-domain-containing adaptor, is specifically involved in TLR4 signaling (Fitzgerald et al., 2003b; Yamamoto et al., 2003b)....
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...Recognition of dsRNA by TLR3 in the endosomal membrane recruits TRIF to the receptor, which induces proinflammatory cytokines and type I IFNs via the RIP1/TRAF6-NF-kB pathway and the TBK1/IKK-i-IRF-3/IRF-7 pathway, respectively....
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...This MyD88-independent pathway is initiated by another TIR-domain-containing adaptor, TRIF (Hoebe et al., 2003; Yamamoto et al., 2003a)....
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...TRIF activates NF-kB and IRF-3, resulting in the induction of proinflammatory cytokine genes and type I IFNs....
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...For example, vaccinia virus produces the TIR-domain-containing proteins A46R and A52R, which target host MyD88 and TRIF, and suppresses TLR- or IL-1R-induced NF-kB activation (Bowie et al., 2000; Stack et al., 2005)....
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7,906 citations
Cites background from "Role of adaptor TRIF in the MyD88-i..."
...By contrast, the TLR-mediated expression of genes that encode inflammatory cytokines is controlled by the MyD88-dependent pathway, although both the MyD88-dependent and -independent pathways are involved in TLR4-mediated production of inflammatory cytokine...
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7,384 citations
Cites background from "Role of adaptor TRIF in the MyD88-i..."
...In addition to MyD88, some TLR ligands can also activate TIR-domain-containing adaptor protein inducing IFNβ (TRIF)-dependent pathways, which signal through IFN-regulatory factor 3 (IRF3) and result in IFNβ productio...
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5,915 citations
3,829 citations
Cites background from "Role of adaptor TRIF in the MyD88-i..."
...Studies using cells from TRIF-deficient mice demonstrate that TRIF is required for early and late NFB responses and IRF3 responses to LPS, but not for JNK activation (M. Yamamoto et al. 2003a; Akira 2004)....
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...TRAM does not function in TLR3 or IL-1R signaling pathways (Fitzgerald et al. 2003; M. Yamamoto et al. 2003b)....
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...Chromatin immunoprecipitation (ChIP) experiments clearly show accumulation of IKK , and perhaps IKK , at the promoter sites of NF- Bresponsive genes (Anest et al. 2003; Y. Yamamoto et al. 2003)....
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...TLR4-induced IRAK activation by MyD88, however, is unaffected by the absence of TRAM (M. Yamamoto et al. 2003b)....
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References
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