Role of ascorbic acid on testicular degeneration in alloxan diabetic rats.
TL;DR: On a observé que l'atrophie degénérative des testicules de rats atteints de diabète provoqué par l'alloxane peut être corrigée par un traitement d'acide ascorbique (vitamine C) administré en hautes doses.
Abstract: On a observe que l'atrophie degenerative des testicules de rats atteints de diabete provoque par l'alloxane peut etre corrigee par un traitement d'acide ascorbique (vitamine C) administre en hautes doses.
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TL;DR: When 5-thio-D-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks, removal from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks.
Abstract: When 5-thio-D-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks. Removal of this substance from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks. Normal litters were sired by males which had recovered after this treatment.
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01 Nov 1999-Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology
TL;DR: Ascorbic acid has a protective effect on alloxan-induced damage by maintaining the activity of cellular antioxidants and the loss of copper and zinc from testes.
Abstract: The diabetic subject is at significantly increased risk of developing testicular changes. Its etiology may involve oxidative damage by free radicals and protection against such damage can be offered by antioxidant supplementation. Alloxan elicited significant inhibition of antioxidants including superoxide dismutase, catalase and glutathione reductase activities and decreased glutathione content in testis. These effects were accompanied by significant elevation of testicular lipid peroxidation, decreased plasma testosterone level and a drop in copper and zinc concentrations in testis. The administration of ascorbic acid after alloxan treatment interfered and prevented alloxan action. Ascorbic acid blunted the increased testicular lipid peroxidation and the decreased plasma testosterone level probably by protecting antioxidants and the loss of copper and zinc from testes. The data suggested that ascorbic acid has a protective effect on alloxan-induced damage by maintaining the activity of cellular antioxidants.
57 citations
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TL;DR: Alloxan diabetes caused a marked stimulation of endogenous oxygen uptake by rat testis tissues, however, the oxygen uptake in the presence of added glucose or pyruvate as substrate was significantly reduced and the ability of theTestis tissues to utilize these substrates and to produce lactate was significantly inhibited in the diabetic animals.
Abstract: Alloxan diabetes caused a marked stimulation of endogenous oxygen uptake by rat testis tissues. However, the oxygen uptake in the presence of added glucose or pyruvate as substrate was significantly reduced. The ability of the testis tissues to utilize these substrates and to produce lactate was significantly inhibited in the diabetic animals. Alloxan diabetes also increased the levels of cholesterol, cholesterol esters, non-esterified fatty acids, triglycerides and phospholipids in rat testis tissues. Treatment of the diabetic rats with ascorbic acid caused more or less a normalization of all the parameters tested.
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TL;DR: It is believed that the gain in adrenal weight, under conditions of stress, is due to an hypertrophy of the cortex with a corresponding increase in Adrenal cortical hormones production, and consequently an increased resistance towards the damaging agent.
Abstract: It is well known that any type of stress produces an increase in weight of the adrenals, and it is believed that the weight response in such conditions is an aspect of the functional adaptation of the adrenals to the increased requirement for cortical hormones by the organism (Selye, 1937) (Ingle, 1938, 1939); in other words, that the gain in adrenal weight, under conditions of stress, is due to an hypertrophy of the cortex with a corresponding increase in adrenal cortical hormones production, and consequently an increased resistance towards the damaging agent. It has also been shown by many authors that the enlargement of the adrenal cortex can be prevented (Ingle, 1938) (Selye, 1940) or even more that the gland may become atrophied (Selye and Dosne, 1942) when the animals under stress are treated with sufficiently high doses of adrenal cortical hormones; moreover,
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01 Jan 1958
TL;DR: Dr. Scott Williamson approaches this problem on the theory that the primary interest is the individual patient, and has no use for schemes whose main solicitude seems to be the community.
Abstract: ior finding out what the doctors in total should receive would be to take their earnings in a year in which they did most work. As to the distribution of the money among the doctors the author is not too clear, for here he strikes the problem of how to distribute a limited pool equitably, and this has defeated all who have tried to solve it. There are patients who are too anxious to be visited and doctors who are too anxious to oblige. This must be met by surcharging the doctors with any excess over the mean, and thus a doctor "whose anxiety exceeded the mean would pay for his idiosyncrasy." This is a bald outline of new and very interesting proposals undoubtedly attractive to many, both patients and doctors. But it all seems too easy-though the author has no doubt about it. It would certainly be opposed by the State Socialists and by the bureaucracy. The author's general philosophy of " Liberal Socialism " is open to criticism at many points. As one example, he says that " Nature hates dying as fiercely as she loves living." It could just as easily be argued that Nature is quite indifferent and that dving is as much a part of Nature as living. This refreshing book can be cordially recommended to all interested in the future of medical service. Over and over again Dr. Scott Williamson emphasizes that he approaches this problem on the theory that the primary interest is the individual patient. He has no use for schemes whose main solicitude seems to be the community. A. C.
36 citations
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11 citations