Role of Endothelial Dysfunction in Atherosclerosis
Citations
5,514 citations
1,811 citations
Cites background from "Role of Endothelial Dysfunction in ..."
...known risk factors for ACVD rather than specifically targeting endothelial-based mechanisms.(36) Looking to the future, the development of pharmacomimetics of the natural, flow-medi-...
[...]
...As we have considered in detail in this review, ECD in response to specific pathophysiological stimuli (eg, hypercholesterolemia and other dyslipidemias, diabetes mellitus, obesity, hypertension, and aging) has important local manifestations within the walls of arteries in lesion-susceptible regions, but also can be detected in nonlesion regions of the vasculature.(36) A systemic context for ECD becomes especially relevant when considering the inter-relationships of type 2 diabetes mellitus, insulin resistance, the metabolic syndrome, and ACVD risk....
[...]
...to flow-mediated reactive hyperemia, have found their way into general practice.(36) The concordance of these measure-...
[...]
...Peripheral manifestations of endothelial dysfunction have also been shown to be an independent predictor of ACVD events.(36) This has stimulated the development and application of various Food and Drug Administration–approved devices to measure flow-mediated arterial dilation as a clinically useful index in the assessment of cardiovascular disease....
[...]
1,753 citations
1,040 citations
771 citations
References
19,881 citations
6,810 citations
"Role of Endothelial Dysfunction in ..." refers background in this paper
...(6) BH4 is a required cofactor for NO synthesis....
[...]
4,604 citations
2,623 citations
2,457 citations