Role of Glutamate and NMDA Receptors in Alzheimer’s Disease
Citations
609 citations
393 citations
238 citations
Cites background from "Role of Glutamate and NMDA Receptor..."
...And this, in turn, rationalizes the clinical trial of memantine, an NMDAR antagonist, as a symptomatological and neuroprotective treatment for AD (Danysz and Parsons, 2003; Wenk, 2006; Wang and Reddy, 2017)....
[...]
...The major factors that affect NMDAR signaling in AD include glutamate availability and the modulation of NMDAR channel functions (Wang and Reddy, 2017)....
[...]
...The toxicity is principally mediated by excessive Ca2+ entry, primarily through NMDARs (Choi, 1987; Tymianski et al., 1993), since NMDARs have a much higher permeability for calcium ions compared to other iGluRs (Choi, 1992; Wang and Reddy, 2017)....
[...]
...However, excessive NMDAR activity causes excitotoxicity and promotes cell death, underlying a potential mechanism of neurodegeneration occurred in AD (Wang and Reddy, 2017)....
[...]
194 citations
Cites result from "Role of Glutamate and NMDA Receptor..."
...Excessive NMDA activity has been demonstrated to cause excitotoxicity, promoting cell death, a probable mechanism of neurodegeneration in AD, in agreement with the GSK-3β hyperactivation hypothesis (70)....
[...]
165 citations
References
8,669 citations
4,979 citations
4,416 citations
4,183 citations
4,179 citations