Role of Immune Cells and Immune-Based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma
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TLDR
Interestingly, chronic pancreatitis and PDA tissues have similarities in their desmoplasia and inflammatory infiltrates, indicating overlapping inflammatory responses, and further studies are needed to determine the differences and similarities of these responses.About:
This article is published in Gastroenterology.The article was published on 2013-05-01 and is currently open access. It has received 242 citations till now. The article focuses on the topics: Pancreatitis & Pancreatitis, chronic.read more
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Journal ArticleDOI
Inflammatory responses and inflammation-associated diseases in organs
Linlin Chen,Huidan Deng,Hengmin Cui,Jing Fang,Zhicai Zuo,Junliang Deng,Yinglun Li,Xun Wang,Ling Zhao +8 more
TL;DR: Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds, potentially leading to tissue damage or disease.
Journal ArticleDOI
The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression
Smruti Pushalkar,Mautin Hundeyin,Donnele Daley,Constantinos P. Zambirinis,Emma Kurz,Ankita Mishra,Navyatha Mohan,Berk Aykut,Mykhaylo Usyk,Luisana E. Torres,Gregor Werba,Kevin Zhang,Yuqi Guo,Qianhao Li,Neha Akkad,Sarah Lall,Benjamin Wadowski,Johana Gutierrez,Juan A. Kochen Rossi,Jeremy Herzog,Brian Diskin,Alejandro Torres-Hernandez,Josh Leinwand,Wei Wang,Pardeep S. Taunk,Shivraj Savadkar,Malvin N. Janal,Anjana Saxena,Xin Li,Deirdre Jill Cohen,R. Balfour Sartor,R. Balfour Sartor,Deepak Saxena,George Miller,George Miller +34 more
TL;DR: It is found that a distinct and abundant microbiome drives suppressive monocytic cellular differentiation in pancreatic cancer via selective Toll-like receptor ligation leading to T-cell anergy, and that the microbiome has potential as a therapeutic target in the modulation of disease progression.
Journal ArticleDOI
PD-1/PD-L1 blockade together with vaccine therapy facilitates effector T-cell infiltration into pancreatic tumors.
Kevin C. Soares,Agnieszka A. Rucki,Annie A. Wu,Kelly Olino,Qian Xiao,Yi Chai,Anthony Wamwea,Elaine Bigelow,Eric R. Lutz,Linda Liu,Sheng Yao,Robert A. Anders,Daniel A. Laheru,Christopher L. Wolfgang,Barish H. Edil,Barish H. Edil,Richard D. Schulick,Richard D. Schulick,Elizabeth M. Jaffee,Lei Zheng +19 more
TL;DR: It is found that PD-L1 is weakly expressed at a low frequency in untreated human and murine PDAs but treatment with a granulocyte macrophage colony-stimulating factor secreting PDA vaccine (GVAX) significantly upregulates PD- L1 membranous expression after treatment of tumor-bearing mice, and combination therapy with vaccine and PD-1 antibody blockade improved murine survival.
Journal ArticleDOI
γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation
Donnele Daley,Constantinos P. Zambirinis,Lena Seifert,Neha Akkad,Navyatha Mohan,Gregor Werba,Rocky Barilla,Alejandro Torres-Hernandez,Mautin Hundeyin,Vishnu R. Mani,Antonina Avanzi,Daniel Tippens,Rajkishen Narayanan,Jung Eun Jang,Elliot Newman,Venu G. Pillarisetty,Michael L. Dustin,Michael L. Dustin,Dafna Bar-Sagi,Cristina H. Hajdu,George Miller +20 more
TL;DR: Greek γδT cells are described as central regulators of effector T cell activation in cancer via novel cross-talk and are identified as critical sources of immune-suppressive checkpoint ligands in PDA.
Journal ArticleDOI
Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer.
Yaqing Zhang,Ashley Velez-Delgado,Esha Mathew,Dongjun Li,Flor M. Mendez,Kevin Flannagan,Andrew D. Rhim,Diane M. Simeone,Gregory L. Beatty,Marina Pasca di Magliano +9 more
TL;DR: Derailing this crosstalk between myeloid cells and tumour cells is sufficient to restore anti-tumour immunity mediated by CD8+ T cells, a finding with implications for the design of immune therapies for pancreatic cancer.
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