Role of Medicinal Plants of Traditional Use in Recuperating Devastating COVID-19 Situation
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TLDR
This article will help researchers and industries to identify and scrutinize potential medicinal plants that can meet their interests for various applications including development of herbal/Ayurvedic antiviral drugs, designing antimicrobial/antiviral materials, development of immunopotentiator, preparation of potential sanitizer systems etc.Abstract:
In the present scenario of COVID-19 strike and lack of potential antiviral medicines/vaccines against this extremely
contagious lethal infection, identifying potential natural plant sources that can help in fighting this disease either by
being viricidal or by boosting the immune system can provide significant therapeutic support. Around the globe as of
26th July 2020, there is ~15.78 million confirmed cases and 0.64 million deaths. The COVID-19 infection is
produced by virulent Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) virus, which belongs to large
corona virus family. These viruses are responsible for many recent infection outbreaks, SARS in 2003, MERS (Middle
East Respiratory Syndrome) in 2012 and recent most fatal COVID-19. Also, mortality rate related to COVID-19 is
found to be very high in case of people with weak immune system e.g. elderly patients, children or patients with preexisting
health problems. In this relevance, medicinal plants can act as potential healing agents that can help people
to fight against this infection by boosting their immune system or by posing viricidal effect. And thus, can contribute
in reducing mortality rate related to SARS-CoV-2 infections. In this review, we attempted to compile and discuss
different traditional medicinal plants and their bioactive components that help in strengthening our immune system
and also play key role in combatting microbial infections including COVID-19. This article will help researchers and
industries to identify and scrutinize potential medicinal plants that can meet their interests for various applications
including development of herbal/Ayurvedic antiviral drugs, designing antimicrobial/antiviral materials, development
of immunopotentiator, preparation of potential sanitizer systems etc.read more
Citations
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Journal ArticleDOI
The use of medicinal plants to prevent COVID-19 in Nepal.
Dipak Khadka,Dipak Khadka,Dipak Khadka,Man Kumar Dhamala,Feifei Li,Prakash Chandra Aryal,Prakash Chandra Aryal,Pappu Rana Magar,Sijar Bhatta,Manju Shree Thakur,Anup Basnet,Dafang Cui,Shi Shi +12 more
TL;DR: People were using more medicinal plants during CO VID-19 claiming that they can prevent or cure COVID-19, and the information source of plants was significantly associated with the education, gender, method of treatment, occupation, living with family, and location of home during lockdown caused by COVID
Journal ArticleDOI
Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Abstract: BACKGROUND AND OBJECTIVE: The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), a highly pathogenic virus, is responsible for a respiratory disease termed coronavirus disease 2019 (COVID-19). SARS-CoV-2 genome encodes various structural and non-structural proteins, which are necessary for viral entry and replication. Among these proteins, papain-like protease (PLpro), 3C-like protease (3CLpro), RNA-dependent RNA polymerase (RdRp), helicase, a serine protease, and spike protein are potential targets of herbal remedies and phytocompounds for inhibition of viral infection and replication. There is at present no confirmed cure for the COVID-19. Various plants and their components have been introduced against SARS-Co-2. A number of review articles have also been published on them. This article is focusing on the mechanistic aspects of these plants and their derivatives on SARS-CV-2. METHOD: The material in this review article was prepared from significant scientific databases, including Web of Science, PubMed, Science Direct, Scopus and Google Scholar. RESULTS: Different medicinal plants and their phytocompounds interact with important structural and non-structural of SARS-CoV-2 proteins. Natural compounds form strong bonds with the active site of SARS-CoV-2 protease and make large conformational changes. These phytochemicals are potential inhibitors of structural and non-structural of SARS-CoV-2 proteins such as Spike protein, PLpro, and 3CLpro. Some important anti-SARS-CoV-2 actions of medicinal plants and their metabolites are inhibition of the virus replication or entry, blocking the angiotensin-converting enzyme 2 (ACE-2) receptor and "Transmembrane protease, serine 2 (TMPRSS2)" regulation of inflammatory mediators, inhibition of endothelial activation, toll-like receptors (TLRs) and activation of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2). Some of these important natural immune boosters that are helpful for prevention and curing various symptoms related to COVID-19 include Allium sativum, Nigella sativa, Glycyrrhiza glabra Zingiber officinalis, Ocimum sanctum, Withania somnifera, Tinospora cordifolia, and Scutellaria baicalensis. Also, Kaempferol, Quercetin, Baicalin, Scutellarin, Glycyrrhizin, Curcumin, Apigenin, Ursolic acid, and Chloroquine are the best candidates for treating the symptoms associated with SARS-CoV-2 infection. CONCLUSION: Medicinal plants and/or their bioactive compounds with inhibitory effects against SARS-CoV-2 support the human immune system and help in fighting against COVID-19 and rejuvenating the immune system.
Journal ArticleDOI
A Cross-Cultural Analysis of Plant Resources among Five Ethnic Groups in the Western Himalayan Region of Jammu and Kashmir
Shiekh Marifatul Haq,Musheerul Hassan,Rainer W. Bussmann,Eduardo Soares Calixto,Inayat Ur Rahman,Shazia Sakhi,Farhana Ijaz,Abeer Hashem,Al-Bandari Fahad Al-Arjani,Khalid F. Almutairi,Elsayed Fathi Abd_Allah,Muhammad Abdul Aziz,Niaz Ali +12 more
TL;DR: In this paper , a study of plant resources from five ethnic communities of the Jammu and Kashmir (J&K) region, Western Himalayas, was conducted from June 2019 to April 2021, during which they recorded a total of 127 plant species used by local ethnic groups for various provisioning services (i.e., medicine, food, fodder, fuelwood, herbal tea) and with spiritual significance.
Journal ArticleDOI
Challenges in Medicinal and Aromatic Plants DNA Barcoding—Lessons from the Lamiaceae
TL;DR: The potential value of DNA barcoding for the identification of medicinal plants and authentication of traded plant materials has been widely recognized; however, a number of challenges remain before DNA methods are fully accepted as an essential quality control method by industry and regulatory authorities.
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