Role of Reactive Oxygen Species in Tumor Necrosis Factor-alpha Induced Endothelial Dysfunction.
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311 citations
Cites background from "Role of Reactive Oxygen Species in ..."
...TNF-α has been suspected to also increase production of free radicals through the activation of XO, although this seems to be controversial [106]....
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...The expression of ICAM-1, VCAM-1, and the chemoattractant protein-1 (MCP-1) is induced by TNF-α and controlled by an ROS-dependent mechanism [106]....
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307 citations
Cites background from "Role of Reactive Oxygen Species in ..."
...TNF- impaired endothelium-dependent and NOmediated vasodilation in various vascular beds (Chen et al., 2008; Zhang et al., 2009a), and a key role for TNFin mediating endothelial dysfunction in ED has been suggested (Carneiro et al., 2009)....
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...TNF- has been shown to play an important role in CV disease, mainly because of its direct effects on the vasculature (Chen et al., 2008; Zhang et al., 2009a), and may also be involved in ED, because high levels of TNF- were demonstrated in patients with ED (Carneiro et al., 2010)....
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References
15,827 citations
"Role of Reactive Oxygen Species in ..." refers background in this paper
...Three distinct iso-forms of NOS have been well characterized and commonly referred as endothelial (eNOS), neuronal (nNOS), and inducible NOS (iNOS) [68]....
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9,131 citations
"Role of Reactive Oxygen Species in ..." refers background in this paper
...ROS form as natural byproducts of the normal metabolism of oxygen and are involved in a variety of cellular processes from cell proliferation to cell adaptation to hypoxia, from apoptosis to carcinogenesis, to maintain or reestablish redox homeostasis, acting as intracellular second messengers or modulating signal transduction pathways [7–9]....
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7,027 citations
"Role of Reactive Oxygen Species in ..." refers background in this paper
...NO does not directly interact with SOD [86]; thus, the effects of SOD on the biological function of NO appear to be due to removal of O2 [87] However, this indicates that ONOO- would also be produced....
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5,682 citations
"Role of Reactive Oxygen Species in ..." refers background in this paper
...Mitochondria, the energy centers of the cell, are the principal site of oxygen metabolism, accounting for approximately 85%–90% of oxygen consumed by cells [21,22]....
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5,514 citations
Additional excerpts
...biology and pathophysiology we suggest [84]....
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