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Role of shear induced diffusion in acoustophoretic focusing of dense suspensions
S. Karthick,Ashis Kumar Sen +1 more
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In this paper, the authors investigate the interplay between acoustic and shear induced diffusion (SID) forces in acoustophoretic focusing of dense suspensions in a microchannel and present a theoretical model which accurately predicts the width of the focused band in terms of shear rate, acoustic energy density, and particle concentration.Abstract:
We investigate the interplay between acoustic and shear induced diffusion (SID) forces in acoustophoretic focusing of dense suspensions in a microchannel. A theoretical model is presented which accurately predicts the width of the focused band in terms of shear rate, acoustic energy density, and particle concentration. The role of SID is clearly demonstrated by switching off the acoustic field, which leads to the instantaneous spreading of the focused band. At a given acoustic energy density and particle concentration, there exists a critical shear rate Γcr above which the focusing of microparticles is prevented. For Γ<Γcr, an equilibrium focused band is formed whose width remains constant downstream.read more
Citations
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Label-free microfluidic sorting of microparticles.
TL;DR: An updated overview of the state of the art for passive label-free microparticle separation, with emphasis on performance and operational conditions is provided and the newly emerging approach based on shear-induced diffusion is highlighted.
Journal ArticleDOI
Improved Understanding of Acoustophoresis and Development of an Acoustofluidic Device for Blood Plasma Separation
S. Karthick,Ashis Kumar Sen +1 more
TL;DR: In this paper, the physics behind the separation of plasma from whole blood using acoustophoresis (movement driven by sound waves) is not well understood, and experiments and simulations are used to provide an improved understanding.
Journal ArticleDOI
Aggregation of a dense suspension of particles in a microwell using surface acoustic wave microcentrifugation
TL;DR: In this article, the authors investigated the aggregation of a dense suspension of particles (volume fraction, = 0.1 ) in a PDMS microwell by employing surface acoustic wave (SAW) microcentrifugation.
Journal ArticleDOI
Cross-stream migration and coalescence of droplets in a microchannel co-flow using magnetophoresis
TL;DR: In this article, the authors studied the mechanism of cross-stream migration and the coalescence of aqueous droplets flowing in an oil-based ferrofluid with a co-flowing aouous stream in the presence of a magnetic field and revealed that the migration phenomenon is governed by the advection and magnetophoretic (τm) time scales.
Journal ArticleDOI
Continuous Droplet Coalescence in a Microchannel Coflow Using Bulk Acoustic Waves
TL;DR: In this article, the authors studied the physics of acoustics-driven coalescence of liquid droplets with a liquid stream and found that the phenomenon is also governed by the acoustic capillary number and relative widths of the coflowing oil and aqueous streams.
References
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Journal ArticleDOI
Curvilinear flows of noncolloidal suspensions: The role of normal stresses
TL;DR: In this article, the role of normal stresses in particle migration and macroscopic spatial variation of the particle volume fraction φ in a mixture of rigid neutrally buoyant spherical particles suspended in Newtonian fluid is examined for curvilinear shear flows.
Journal ArticleDOI
Shear-induced dispersion in a dilute suspension of rough spheres
F. R. Da Cunha,E. J. Hinch +1 more
TL;DR: In this article, the authors calculate the change between the initial and final streamlines caused by roughness, and calculate the shear-induced diffusivity for both self-diffusion and down-gradient diffusion.
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Acoustic whole blood plasmapheresis chip for prostate specific antigen microarray diagnostics.
Andreas Lenshof,Asilah Ahmad-Tajudin,Kerstin Järås,Ann-Margret Swärd-Nilsson,Lena Åberg,György Marko-Varga,Johan Malm,Hans Lilja,Thomas Laurell +8 more
TL;DR: An acoustophoresis based separation chip that prepares diagnostic plasma from whole blood linked to a clinical application that has the capacity to sequentially remove enriched blood cells in multiple steps to yield high quality plasma of low cellular content is reported on.
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Acoustofluidics 5: Building microfluidic acoustic resonators.
TL;DR: This tutorial covers some of the basics in designing and building microfluidic acoustic resonators and will hopefully be a comprehensive and advisory document to assist the interested reader in creating a successful acoustophoretic device.
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Advances in the measurement of red blood cell deformability: A brief review
TL;DR: The major determinants of RBC deformability are discussed, which include cell geometry, internal viscosity, rheological properties of the membrane, osmotic pressure, calcium, nitric oxide, temperature, ageing, and depletion of adenosine triphosphate.