Role of the polycomb group proteins in hematopoietic stem cells.
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Cites background from "Role of the polycomb group proteins..."
...PcG genes have been implicated in the maintenance of self-renewing somatic and cancer stem cells (Konuma et al., 2010; Sauvageau and Sauvageau, 2010) and have typically been characterized as oncogenes, as exemplified by somatic activating mutations of EZH2 in follicular and diffuse large B cell…...
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"Role of the polycomb group proteins..." refers background in this paper
...Epigenetic mechanisms involve DNA methylation, histone modifications, and regulation of chromatin structure (Jaenisch & Bird 2003), and play a key role in cellular memory, the ability of cells to remember through subsequent cell divisions their gene expression patterns that have been initiated by…...
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5,131 citations
"Role of the polycomb group proteins..." refers background in this paper
...Nonetheless, it remains controversial whether CBX proteins recruit PRC1 directly to H3K27me3-marked chromatin (Bernstein et al. 2006b; Ren et al. 2008)....
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...…regulator gene promoters with bivalent domains consisting of overlapping repressive (H3K27me3) and activating (H3K4me3) histone modifications to keep developmental regulators ‘‘poised’’ for activation in ES cells (Bernstein et al. 2006a; Spivakov & Fisher 2007; Mendenhall & Bernstein 2008)....
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"Role of the polycomb group proteins..." refers background in this paper
...PcG proteins are classified into at least two functionally and biochemically distinct multimeric complexes, termed Polycomb repressive complexes (PRCs): an initiation complex, PRC2, and a maintenance complex, PRC1 (Table 1) (Sparmann & van Lohuizen 2006; Rajasekhar & Begemann 2007; Simon & Kingston 2009)....
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...In this model, PRC2 is recruited to target gene promoters by accessory proteins, such as the sequence-specific DNA-binding protein YY1, and induces H3K27me3 marks....
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...In contrast, PRC1 ion established by PRC2....
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...In contrast, the H3K4me2 ⁄ 3-specific demethylases of JARID (Jumonjiand ARID-domain containing protein) subfamily has been identified to closely associate with PRC2 (Agger et al. 2008; Lan et al. 2008)....
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...However, we do not know what happens in HSCs if the catalytic activity of either PRC1 or PRC2 is completely abolished....
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