Roles of circular RNAs in colorectal cancer.
Mingying Zhang,Shubin Wang +1 more
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TLDR
In this paper, the current body of knowledge on the biogenesis and functions of CRC-associated circRNAs, and their potential value in clinical applications, such as in CRC diagnosis, prognosis and treatment, is discussed and summarized.Abstract:
Colorectal cancer (CRC) is one of the most common types of malignant cancer worldwide and poses a significant burden on both the individual and healthcare systems. Despite advances in treatment options, advanced-stage CRC has a high mortality rate due to its heterogeneity, metastatic potential and/or delay in diagnosis. In recent years, an increasing number of studies have indicated that circular RNAs (circRNAs) serve important roles in several types of cancer, including CRC. Recent studies have revealed that circRNAs are aberrantly expressed in CRC tissues and function as oncogenic or tumor suppressive regulators of CRC carcinogenesis and development. Numerous circRNAs have been associated with the clinicopathological features of patients with CRC and have been considered as potential biomarkers for the diagnosis and prognosis of CRC, as well as targets for treatment. However, a deeper understanding of their potential function is required. In the present review, the current body of knowledge on the biogenesis and functions of CRC-associated circRNAs, and their potential value in clinical applications, such as in CRC diagnosis, prognosis and treatment, is discussed and summarized.read more
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The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance
Dimitra Ioanna Lampropoulou,Evangelia Pliakou,Gerassimos Aravantinos,Dimitrios Filippou,Maria Gazouli +4 more
TL;DR: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance and has emerged as a promising field for research in order to discover novel biomarkers for therapy monitoring and/or reverse drug desensitization.
Journal ArticleDOI
The hsa_circ_0039857/miR-338-3p/RAB32 axis promotes the malignant progression of colorectal cancer
TL;DR: In this article , the authors explored the function and mechanism of hsa_circ_0039857 in colorectal cancer (CRC) using RT-qPCR and functional experiments, such as proliferation and apoptosis, were applied to study the function of circ.
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