Journal ArticleDOI
Roles of long noncoding RNAs in brain development, functional diversification and neurodegenerative diseases.
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TLDR
A systematic and comprehensive summary of the existing knowledge of lncRNAs is given in order to provide a better understanding of this new studying field and highlight recent studies related lnc RNAs in central nervous system development and neurodegenerative diseases.About:
This article is published in Brain Research Bulletin.The article was published on 2013-08-01. It has received 311 citations till now.read more
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Journal ArticleDOI
Non-coding RNA: what is functional and what is junk?
TL;DR: How to determine whether any given ncRNA has a function is discussed, and it is advocated that in the absence of any such data, the appropriate null hypothesis is that the RNA in question is junk.
Journal ArticleDOI
Competing endogenous RNAs (ceRNAs): new entrants to the intricacies of gene regulation
TL;DR: Decoding the crosstalk between MREs mediated by ceRNAs is critical to delineate the intricacies in gene regulation, and the authors have just begun to unravel this complexity.
Journal ArticleDOI
Neighboring Gene Regulation by Antisense Long Non-Coding RNAs
TL;DR: Functional studies of antisense lncRNA-mediated regulation of neighboring gene expression are addressed, addressing how these transcripts interact with other biological molecules, nucleic acids and proteins, to regulate gene expression through chromatin remodeling at the pretranscriptional level and modulation of transcriptional and post-transcriptional processes.
Evidence of Abundant Purifying Selection in Humans for Recently Acquired Regulatory Functions
TL;DR: In this paper, a broad range of transcribed and regulatory nonconserved elements show decreased human diversity, suggesting lineage-specific purifying selection, while conserved elements lacking activity show increased human diversity.
Journal ArticleDOI
RNA-binding proteins in neurodegeneration: mechanisms in aggregate.
Erin G Conlon,James L. Manley +1 more
TL;DR: This review discusses a prominent theory supported by genetic and pathological changes in an array of neurodegenerative diseases: that neurons are particularly vulnerable to disruption of RNA-binding protein dosage and dynamics and concludes that this perspective offers the most parsimonious explanation for these mysterious diseases.
References
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The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Genome-wide atlas of gene expression in the adult mouse brain
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TL;DR: An anatomically comprehensive digital atlas containing the expression patterns of ∼20,000 genes in the adult mouse brain is described, providing an open, primary data resource for a wide variety of further studies concerning brain organization and function.
Journal ArticleDOI
Long non-coding RNAs: insights into functions
TL;DR: The rapidly advancing field of long ncRNAs is reviewed, describing their conservation, their organization in the genome and their roles in gene regulation, and the medical implications.
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